Results 51 to 60 of about 473,777 (297)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Journal of International Medical Research, 2020 Objective This study was designed to compare the margin clearance and re-excision rates of ultrasound (US)- and wire-guided excision in a large number of patients with nonpalpable breast cancer.
Xin Hu +6 more
doaj +1 more source
, 2012 Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting effect of cancer therapy. The neuropathic pain associated with CIPN often has negative implications on an individual’s quality of life (QOL) and has long been ...
Drury, Daniel G., Wonders, Karen Y.
core +1 more source
TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione [PDF]
, 2016 Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of ...
Benemei, Silvia +15 more
core +1 more source
Migraine, headache, and mortality in women: a cohort study [PDF]
, 2020 Background: Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased risk of cardiovascular mortality.
Buring, Julie Elizabeth +3 more
core +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
A Study Comparing Centchroman and Evening Primrose Oil in the Treatment of Benign Breast Disease
Journal of Pharmacy and Bioallied SciencesIntroductionFemales seeking medical attention at breast clinics commonly present with nonmalignant breast conditions, including nonspecific breast pain or distinct masses like fibroadenomas.
Sinha Nirupam +4 more
doaj +1 more source
Relationship of Body Mass Index with Chronic Pain after Breast Surgery in Women with Breast Cancer [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2019 Introduction: Awareness of prevalence of chronic pain after breast cancer surgery and possible contributing factors in the continuation of pain after breast cancer treatment is essential in preventing this pain in improving the quality of life in ...
Majid Montazer +3 more
doaj +1 more source
Post-Breast Surgery Pain Syndrome: Shifting a Surgical Paradigm
Plastic and Reconstructive Surgery, Global Open, 2021 Summary:. Post-mastectomy pain syndrome and the less well-described post-breast surgery pain syndrome are long-term neuropathic pain conditions that may affect more than 50% of patients after mastectomy and breast surgery.
Maureen Beederman, MD, Jonathan Bank, MD
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source