Results 151 to 160 of about 4,164 (212)

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

Imaging the Tumor Microenvironment Beyond Anatomy: Functional, Immune, Stromal, and Metabolic Signatures for Precision Oncology

iRADIOLOGY, EarlyView.
This article highlights the importance of imaging the tumor microenvironment (TME) beyond conventional anatomy‐based approaches to enable more precise oncology. It focuses on capturing key biological dimensions of tumors—vascular function and hypoxia, immune response, stromal remodeling, and metabolic activity—using advanced imaging techniques.
Karthikeyan Elumalai, Gayathri Krishnakumar   +1 more
wiley   +1 more source

Clinical Rationale of Dual‐Parameter Tumor Markers Reporting Without Reliance on Normal Reference Ranges

Journal of Clinical Laboratory Analysis, EarlyView.
We recommend the current practice of tumor marker reporting to upgrade to two‐figure format to include a specific growth rate in parentheses. This can be of great clinical importance, especially in the subnormal range. ABSTRACT Introduction This review offers clinicians a novel view of tumor markers (TM).
Jurate Civinskaite, Daiva Gudaviciene, Gintaras Zaleskis, Aleksandras Petrauskas, Dainius Characiejus, Tatjana Ivaskiene   +5 more
wiley   +1 more source

Improved Post‐Processing Framework for Whole Slide Imaging and 3D Reconstruction

Microscopy Research and Technique, EarlyView.
Workflow for 3D reconstruction of marmoset whole‐slide histology. Individual tiles undergo vignette correction to address illumination artifacts before stitching into full‐section images. Sections are then reconstructed using the Possum framework, with a level‐set method incorporated at the nonlinear deformable stage to stabilize alignment and reduce ...
Emily L. De Leon Alvarado, Daryan Chitsaz, Ilana R. Leppert, Jennifer S. W. Campbell, Yangyingqi Zhou, G. Bruce Pike, Timothy E. Kennedy, Christine L. Tardif, Christopher D. Rowley   +8 more
wiley   +1 more source

Hospital Volume and Operative Mortality in Pancreaticoduodenectomy and Hepatectomy: Analysis of the National Clinical Database in Japan

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose This study evaluated the association between institutional advanced hepatobiliary‐pancreatic (HBP) surgical volume and operative mortality for pancreaticoduodenectomy (PD) and advanced hepatectomy using data from the Japanese National Clinical Database.
Yoshitaro Shindo, Hideki Endo, Hiroyuki Yamamoto, Hidenori Takahashi, Shigeru Marubashi, Atsushi Nanashima, Itaru Endo, Hideki Ueno, Ken Shirabe, Masafumi Nakamura, Hiroaki Nagano, Masayuki Ohtsuka   +11 more
wiley   +1 more source

Breast reconstruction [PDF]

Ca-A Cancer Journal for Clinicians, 1993
exaly   +3 more sources

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Breast Reconstruction

Clinical Obstetrics and Gynecology, 2006
With over 200,000 new cases of invasive breast cancer treated each year, various types of breast reconstruction have become popular and safe. Immediate breast reconstruction seems to confer both benefit and patient satisfaction. A variety of techniques including subcutaneous expanders/implants, flap transfers, and free tissue transfers are described.
Justin H, Piasecki, Karol A, Gutowski
openaire   +2 more sources

Breast Reconstruction

Surgical Clinics of North America, 2013
As diagnostic technology has progressed and the understanding of the disease process has evolved, the number of mastectomies performed in the United States has increased. Breast reconstructive techniques have commensurately become more sophisticated along the same timeline. The result is that those facing mastectomy have the potential to simultaneously
Frank J, DellaCroce, Emily T, Wolfe
openaire   +2 more sources

Prepectoral Breast Reconstruction

Clinics in Plastic Surgery, 2023
Prepectoral breast reconstruction has gained popularity due to numerous benefits in properly selected patients. Compared with subpectoral implant reconstruction, prepectoral reconstruction offers preservation of the pectoralis major muscle in its native position, resulting in decreased pain, no animation deformity, and improved arm range of motion ...
Francis D, Graziano, Jocelyn, Lu, Hani, Sbitany   +2 more
openaire   +2 more sources