Results 151 to 160 of about 189,014 (298)
Advanced NanoBiomed Research, EarlyView.Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura +14 more
wiley +1 more source
Nanoclay‐Engineered Scaffolds for the Controlled Delivery of Biomolecules in Regenerative Medicine
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT Regenerative medicine combines biomaterials, cells, scaffolds, and bioactive agents via modern technologies to aid in the reconstruction and repair of damaged tissues. Among these, nanoclay scaffolds have demonstrated unique advantages in facilitating the delivery of therapeutic agents.
Mehri Shadi +2 more
wiley +1 more source
Patient Choice: Autonomy and Ethics in Breast Reconstruction. [PDF]
Ann Plast SurgBastin N, Saad M, Kubiak CA, Drolet BC.
europepmc +1 more source
Trabecular bone ontogeny of the human talus
The Anatomical Record, EarlyView.Abstract Studies of trabecular ontogeny may provide insight into the factors that drive healthy bone development. There is a growing understanding of how the juvenile skeleton responds to these influences; however, gaps in our knowledge remain. This study aims to identify ontogenetic trabecular patterns and regional changes during development within ...
Rebecca A. G. Reid +2 more
wiley +1 more source
Applications of the Fold Flap in Breast Reconstruction. [PDF]
Plast Reconstr Surg Glob OpenBaccarani A, Pappalardo M.
europepmc +1 more source
Arthroscopy, EarlyView.Purpose To investigate location‐ and sex‐specific glenoid labrum morphology of healthy young adults in vivo, and the labrum's effects on depth and radius of curvature (ROC) of the glenohumeral joint. Methods Healthy young adults with no history of shoulder surgery, injury, or instability underwent computed tomography and magnetic resonance imaging ...
Ryan J. Kelly +5 more
wiley +1 more source
Breast reconstruction following mastectomy [PDF]
, 2006 Andriushchenko, Volodymyr Viktorovych +2 more
core
Arthritis &Rheumatology, EarlyView.Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng +6 more
wiley +1 more source
Transfer Learning Approaches in Bioprocess Engineering: Opportunities and Challenges
Biotechnology and Bioengineering, EarlyView.ABSTRACT Transfer learning (TL) has recently emerged as a promising approach to overcoming one of the key limitations of bioprocess engineering: data scarcity. By leveraging knowledge from one bioprocess to another, TL allows existing models and data sets to be reused efficiently, accelerating process development, improving prediction accuracy, and ...
Daniel Barón Díaz +3 more
wiley +1 more source
On the Prediction of pDNA Productivity Across Diverse Bioprocesses Using Ensemble Hybrid Models
Biotechnology and Bioengineering, EarlyView.ABSTRACT The global demand for plasmid DNA (pDNA) is rapidly increasing due to its key role in the manufacture of mRNA vaccines and advanced therapy medicinal products (ATMPs). However, the reliance on suboptimal batch and/or fed‐batch processes, as well as the diversity and increasing complexity of plasmid constructs pose significant challenges during
Nikolaos Stratis +2 more
wiley +1 more source