Results 241 to 250 of about 300,662 (322)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Assessment of skills among women of reproductive age group trained in breast self-examination: A quasiexperimental study. [PDF]

J Family Med Prim Care
Singh T, Singh MM, Rao S, Borle AL.
europepmc   +1 more source

Multi‐Scale Mapping of Gene Expression from Whole‐slide Images for Identifying Phenotype‐Associated Subpopulations

Advanced Science, EarlyView.
BiSCALE: A pathology‐driven deep learning framework for multi‐scale gene expression prediction from whole‐slide images. It accurately infers bulk and near‐cellular spot‐level expression, links predictions to clinical phenotypes, identifies disease‐associated niches, and enables applications in risk stratification and cell‐identity annotation, providing
Hailong Zheng, Jiajing Xie, Luqi Wang, Hailong Xie, Tong Zhi, Yujia Guo, Bofeng Zhu, Dong Wang, Yu Chen   +8 more
wiley   +1 more source

Breast self-examination.

The Western journal of medicine, 2010
L, Mahoney, A, Csima
openaire   +3 more sources

Quality Assessment of YouTube Videos As Information Source for Breast Self-Examination. [PDF]

Cureus
Bu Bshait MS, Almaqhawi A.
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Get to know your breasts : A market research concerning AWARE Breast self-examination pad

, 2005
Leni Andersson, Nina Nordell, Annie Wong
openalex   +1 more source

[BARRIERS ASSOCIATED WITH BREAST SELF-EXAMINATION AMONG WOMEN 18 TO 50 YEARS OLD: A CROSS SECTIONAL STUDY].

, 2015
Javier Martínez Martínez, César Eduardo Pabón-Rozo, Natalia Quintero-Contreras, Jordán Soto Galván, Rafael López-Mayorga, Yeinly Rojas-Tinico, Robinson Ramírez‐Vélez   +6 more
openalex   +2 more sources

The effect of a virtual educational intervention based on self-efficacy theory on women's skills of breast self- examination. [PDF]

BMC Womens Health
Kucheki M, Nazari M, Arshadinejad R, Karimi M.   +3 more
europepmc   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source