Results 91 to 100 of about 423,499 (340)

Building social capital through breastfeeding peer support: Insights from an evaluation of a voluntary breastfeeding peer support service in North-West England [PDF]

open access: yes, 2015
Background: Peer support is reported to be a key method to help build social capital in communities. To date there are no studies that describe how this can be achieved through a breastfeeding peer support service.
A Aiken   +80 more
core   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel   +12 more
wiley   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove   +4 more
wiley   +1 more source

Diet at birth is critical for healthy growth, independent of effects on the gut microbiota

open access: yesMicrobiome
Background Colostrum is the first milk for a newborn. Its high content in microbiota shaping compounds and its intake at the time of gut microbiota seeding suggests colostrum may be critical in the establishment of a healthy microbiota.
Lieke J. W. van den Elsen   +12 more
doaj   +1 more source

Got Caries? Breast milk and Early Childhood Caries? [PDF]

open access: yes, 2018
Objective: To provide an analysis of the association between the longevity of breastfeeding and development of ECC. Determine the optimal time frame in which mothers should cease breastfeeding to reduce ECC development. Methods: Dr.
Dean, Megan L.   +2 more
core   +2 more sources

Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations

open access: yesNature Communications, 2018
Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to ...
N. Ho   +19 more
semanticscholar   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić   +7 more
wiley   +1 more source

A case presentation of Voriconazole therapy in a brochopulmonary dysplasia [PDF]

open access: yesIranian Journal of Neonatology, 2015
Premature infants may be more vulnerable to fungal infections because of their immature immune system, poorly developed epithelial skin and mucosal barriers, and the high rate of invasive procedures, such as central venous catheters and intubation, which
Elaheh Amini   +5 more
doaj   +2 more sources

Dynamic Modelling of Child Mortality in Developing Countries: Application for Zambia [PDF]

open access: yes, 2002
In this paper, we analyse the causes of under five mortality in Zambia, with a particular emphasis on assessing possible time-variations in the effects of covariates, i.e. whether the effects of certain covariates vary with the age of the child.
Berger, U., Fahrmeir, Ludwig, Klasen, S.
core   +1 more source

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