Results 51 to 60 of about 156,660 (295)

Probability of pharmacokinetic/pharmacodynamic target attainment for different piperacillin/tazobactam dosing regimens in renally impaired patients in a non‐intensive care unit setting

British Journal of Clinical Pharmacology, EarlyView.
Aims To optimize antibiotic therapy for pathogens classified as susceptible, increased exposure (I), an increased exposure of piperacillin/tazobactam (PTZ) is required. However, dosing recommendations are currently only available for patients with normal renal function.
Emma Dohmann, Stefan Hagel, Max Kurlbaum, Paul Schellong, Oliver Scherf‐Clavel, Güzin Surat   +5 more
wiley   +1 more source

Diet at birth is critical for healthy growth, independent of effects on the gut microbiota

Microbiome
Background Colostrum is the first milk for a newborn. Its high content in microbiota shaping compounds and its intake at the time of gut microbiota seeding suggests colostrum may be critical in the establishment of a healthy microbiota.
Lieke J. W. van den Elsen, Akila Rekima, Miriam A. Lynn, Charlotte Isnard, Savannah Machado, Nivedithaa Divakara, Diana Patalwala, Alana Middleton, Natalie Stevens, Florence Servant, Remy Burcelin, David J. Lynn, Valerie Verhasselt   +12 more
doaj   +1 more source

Pharmacokinetics and Safety Evaluation of a New Generic Sitafloxacin: A Phase I Bioequivalence Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei, Pan Luo, Yuzhu Chen, Liuliang Xue, Donglin Zhang, Xingxing Qi, Yinian Fang, Hengyi Yu, Zheng He, Qin Zuo, Chang Liu, Dong Liu, Xinhua Ren, Qian Chen   +13 more
wiley   +1 more source

Donor human milk practice in Indonesia: a media content analysis

Frontiers in Nutrition
IntroductionDonor human milk (DHM) is recommended as the second-best alternative form of supplementation when a mother is unable to breastfeed directly.
Andini Pramono, Andini Pramono, Alvia Hikmawati   +2 more
doaj   +1 more source

Policy content and stakeholder network analysis for infant and young child feeding in Bangladesh

BMC Public Health, 2017
Background Appropriate infant and young child feeding (IYCF) practices are essential for nutrition of infants and young children. Bangladesh has one of the highest levels of malnutrition globally along with sub-optimal IYCF practices. A supportive policy
Sabrina Rasheed, Swapan Kumar Roy, Susmita Das, Syeda Nafisa Chowdhury, Mohammad Iqbal, Syeda Mahsina Akter, Khurshid Jahan, Shahadat Uddin, Anne Marie Thow   +8 more
doaj   +1 more source

The nine stages of skin‐to‐skin: practical guidelines and insights from four countries

Maternal and Child Nutrition, 2020
Incorporating systematic evidence with clinical expertise is a key element in the quest to improve quality of care and patient outcomes. The evidence supporting skin‐to‐skin contact in the first hour after birth is robust and includes significantly ...
Kajsa Brimdyr, Karin Cadwell, Kristin Svensson, Yuki Takahashi, Eva Nissen, Ann‐Marie Widström   +5 more
doaj   +1 more source

A Joint Pharmacometric Model of Iohexol and Creatinine Administered through a Meat Meal to Assess GFR and Renal OCT2/MATE Activity

Clinical Pharmacology &Therapeutics, EarlyView.
Accurately assessing glomerular filtration rate (GFR) from plasma creatinine concentrations is challenging in patients with unstable renal function. This study aimed to refine the understanding of creatinine kinetics for more reliable assessments of GFR and net creatinine tubular secretion (nCTS) via OCT2/MATE in humans.
Zhendong Chen, Qian Dong, Charalambos Dokos, Jana Boland, Uwe Fuhr, Max Taubert   +5 more
wiley   +1 more source

Maternal, Infant Characteristics, Breastfeeding Techniques, and Initiation: Structural Equation Modeling Approaches. [PDF]

PLoS ONE, 2015
The aim of this study was to examine the relationships among maternal and infant characteristics, breastfeeding techniques, and exclusive breastfeeding initiation in different modes of birth using structural equation modeling approaches.We examined a ...
Ying Lau, Tha Pyai Htun, Peng Im Lim, Sarah Ho-Lim, Piyanee Klainin-Yobas   +4 more
doaj   +1 more source

Populations Addressed in Vaccines Approved via the European Medicines Agency

Clinical Pharmacology &Therapeutics, EarlyView.
Therapeutic and prophylactic agents require robust evidence before patient use. Randomized controlled trials are essential for evaluating safety and efficacy but often exclude specific populations that are also targets for the intervention. This study assessed which populations are included in vaccine registration studies and/or addressed in label ...
Débora D. Gräf, Lukas Westphal, Jonathan Kimmelman, Christine E. Hallgreen   +3 more
wiley   +1 more source

Absolute Oral Bioavailability and Bioequivalence of LSD Base and Tartrate in a Double‐Blind, Placebo‐Controlled, Crossover Study

Clinical Pharmacology &Therapeutics, EarlyView.
Lysergic acid diethylamide (LSD) is currently being investigated as a potential treatment for psychiatric and neurological disorders. Different LSD formulations (base or tartrate, oral or intravenous) are being used. Unclear is whether LSD base and tartrate pharmacokinetics are equivalent.
Denis Arikci, Friederike Holze, Lorenz Mueller, Patrick Vizeli, Deborah Rudin, Dino Luethi, Cedric M. Hysek, Matthias E. Liechti   +7 more
wiley   +1 more source