Results 11 to 20 of about 390,031 (263)

Critical cysteines in the functional interaction of adenylyl cyclase isoform 6 with Gαs

FASEB BioAdvances, 2022
Activation of adenylyl cyclases (ACs) by G‐protein Gαs catalyzes the production of cyclic adenosine monophosphate (cAMP), a key second messenger that regulates diverse physiological responses.
Anjali Y. Bhagirath, Vikram Bhatia, Manoj Reddy Medapati, Nisha Singh, Martha Hinton, Prashen Chelikani, Shyamala Dakshinamurti   +6 more
doaj   +1 more source

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin

Biology, 2023
Background: The adenylyl cyclase (AC) pathway, crucial for pulmonary vasodilation, is inhibited by hypoxia. Forskolin (FSK) binds allosterically to AC, stimulating ATP catalysis.
Vikram Bhatia, Saeid Maghsoudi, Martha Hinton, Anjali Y. Bhagirath, Nisha Singh, Appalaraju Jaggupilli, Prashen Chelikani, Shyamala Dakshinamurti   +7 more
doaj   +1 more source

Magnitude and Mechanism of Phrenic Long-term Facilitation Shift Between Daily Rest Versus Active Phase

Function, 2023
Plasticity is a fundamental property of the neural system controlling breathing. One key example of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a persistent increase in phrenic nerve activity elicited by acute intermittent ...
Alexandria B Marciante, Yasin B Seven, Mia N Kelly, Raphael R Perim, Gordon S Mitchell   +4 more
doaj   +1 more source

Can we still do something-and what? - for a seemingly missing syndrome?: “Yes we can”

Italian Journal of Pediatrics, 2019
In this letter, the authors compare the incidence of SUDI and SIDS in the Tuscany Region to the incidence reported by Campi and Bonati in their paper “Can we still do something-and what?- for a seemingly missing syndrome?” that was recently published in ...
Raffaele Piumelli, Cinzia Arzilli, Niccolò Nassi, Marta Peruzzi, Carola-Maria Ernst, Cristina Salvatori   +5 more
doaj   +1 more source

Thyroid-Related Hormone Levels in Clinical Patients With Moderately Severe-to-Profound Sudden Sensorineural Hearing Loss: A Prospective Study

Frontiers in Neurology, 2021
Objectives: Sudden sensorineural hearing loss (SSNHL) is a common otological emergency, causing a measure of hearing loss and affecting the quality of life.
Zhong Zheng, Zhong Zheng, Ying Shen, Ying Shen, Liang Xia, Liang Xia, Lili Xiao, Lili Xiao, Yuanyuan Sun, Yuanyuan Sun, Hui Wang, Hui Wang, Zhengnong Chen, Zhengnong Chen, Yaqin Wu, Yaqin Wu, Haibo Shi, Haibo Shi, Jingchun He, Yanmei Feng, Yanmei Feng, Shankai Yin, Shankai Yin   +22 more
doaj   +1 more source

Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms

eLife, 2023
Opioids depress breathing by inhibition of interconnected respiratory nuclei in the pons and medulla. Mu opioid receptor (MOR) agonists directly hyperpolarize a population of neurons in the dorsolateral pons, particularly the Kölliker-Fuse (KF) nucleus ...
Jordan T Bateman, Erica S Levitt
doaj   +1 more source

MicroRNA-200b regulates distal airway development by maintaining epithelial integrity

Scientific Reports, 2017
miR-200b plays a role in epithelial-to-mesenchymal transition (EMT) in cancer. We recently reported abnormal expression of miR-200b in the context of human pulmonary hypoplasia in congenital diaphragmatic hernia (CDH).
Naghmeh Khoshgoo, Robin Visser, Landon Falk, Chelsea A. Day, Dustin Ameis, Barbara M. Iwasiow, Fuqin Zhu, Arzu Öztürk, Sujata Basu, Molly Pind, Agnes Fresnosa, Mike Jackson, Vinaya Kumar Siragam, Gerald Stelmack, Geoffrey G. Hicks, Andrew J. Halayko, Richard Keijzer   +16 more
doaj   +1 more source

Mask pressure effects on the nasal bridge during short-term noninvasive ventilation

ERJ Open Research, 2018
The aim of this study was to assess the influence of different masks, ventilator settings and body positions on the pressure exerted on the nasal bridge by the mask and subjective comfort during noninvasive ventilation (NIV).
Anne-Kathrin Brill, Rachel Pickersgill, Mohammad Moghal, Mary J. Morrell, Anita K. Simonds   +4 more
doaj   +1 more source

Understanding the clinical management of obstructive sleep apnoea in tetraplegia: a qualitative study using the theoretical domains framework

BMC Health Services Research, 2019
Background Clinical practice guidelines recommend further testing for people with tetraplegia and signs and symptoms of obstructive sleep apnoea (OSA), followed by treatment with positive airway pressure therapy.
Marnie Graco, David J. Berlowitz, Sally E. Green   +2 more
doaj   +1 more source

Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study

Frontiers in Neurology, 2021
Objectives: As a common otology emergency, sudden sensorineural hearing loss (SSNHL) has a great impact on quality of life. The diagnosis and treatment of SSNHL remain challenging.
Zhong Zheng, Zhong Zheng, Chengqi Liu, Chengqi Liu, Ying Shen, Ying Shen, Liang Xia, Liang Xia, Lili Xiao, Lili Xiao, Yuanyuan Sun, Yuanyuan Sun, Hui Wang, Hui Wang, Zhengnong Chen, Zhengnong Chen, Yaqin Wu, Yaqin Wu, Haibo Shi, Haibo Shi, Yanmei Feng, Yanmei Feng, Shankai Yin, Shankai Yin   +23 more
doaj   +1 more source