Results 51 to 60 of about 1,214,191 (402)

Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish

eLife, 2021
An opioid epidemic is spreading in North America with millions of opioid overdoses annually. Opioid drugs, like fentanyl, target the mu opioid receptor system and induce potentially lethal respiratory depression.
Shenhab Zaig, Carolina da Silveira Scarpellini, Gaspard Montandon   +2 more
doaj   +1 more source

Breathing feedback system with wearable textile sensors [PDF]

, 2010
Breathing exercises form an essential part of the treatment for respiratory illnesses such as cystic fibrosis. Ideally these exercises should be performed on a daily basis.
Coyle, Shirley, Diamond, Dermot, Mitchell, Edmond, O'Connor, Noel E., Ward, Tomás E.   +4 more
core   +2 more sources

Polysomnographic titration of non-invasive ventilation in motor neurone disease (3TLA): protocol for a process evaluation of a clinical trial

Trials
Background We are undertaking a multicentre randomised controlled trial to determine the effectiveness of including a sleep study (polysomnography (PSG)) to assist the commencement of non-invasive ventilation (NIV) in people with motor neurone disease ...
Marnie Graco, David J. Berlowitz, Abbey Sawyer, Anne E. Holland, Kate A. Carey, Yasmin Ahamed, Anna Ridgers, Natasha A. Lannin, the 3TLA trial Group   +8 more
doaj   +1 more source

ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression

eLife, 2021
Opioids are perhaps the most effective analgesics in medicine. However, between 1999 and 2018, over 400,000 people in the United States died from opioid overdose.
Iris Bachmutsky, Xin Paul Wei, Adelae Durand, Kevin Yackle   +3 more
doaj   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Effect of pulmonary rehabilitation on all-cause mortality in patients with chronic respiratory disease: a retrospective cohort study in an Australian teaching hospital

BMC Pulmonary Medicine
Background Pulmonary rehabilitation (PR) is widely recommended for short-term benefits in chronic respiratory diseases, yet long-term outcomes remain uncertain. This retrospective cohort study addresses this gap, comparing 20-year mortality rates between
Vahid Sharifi, Danny J. Brazzale, Christine F. McDonald, Catherine J. Hill, Chris Michael, Warren R. Ruehland, David J. Berlowitz   +6 more
doaj   +1 more source

A Validated Model to Predict Severe Weight Loss in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Severe weight loss in amyotrophic lateral sclerosis (ALS) is common, multifactorial, and associated with shortened survival. Using longitudinal weight data from over 6000 patients with ALS across three cohorts, we built an accelerated failure time model to predict the risk of future severe (≥ 10%) weight loss using five single‐timepoint ...
David G. Lester, Kevin Talbot, Martin R. Turner, Alexander G. Thompson, the Pooled Resource Open‐Access ALS Clinical Trials Consortium   +4 more
wiley   +1 more source

Effects of SoundBite Bone Conduction Hearing Aids on Speech Recognition and Quality of Life in Patients with Single-Sided Deafness

Neural Plasticity, 2020
Objectives. To analyze the clinical application of SoundBite bone conduction hearing aids by assessing the improvement of speech recognition and the scores of the benefit scale questionnaire for patients with single-sided deafness (SSD). Design.
Qiong Luo, Ying Shen, Ting Chen, Zhong Zheng, Haibo Shi, Yanmei Feng, Zhengnong Chen   +6 more
doaj   +1 more source

Computer Modeling of D, L – Homocysteic Acid Microinjection into the Bötzinger Complex Area

Acta Medica Martiniana, 2022
The impact of D,L – homocysteic acid (DLH) microinjection (non-specific glutamate receptor agonist that causes excitation of neurons) into the Bötzinger complex area (BOT) was simulated using computer model of quiet breathing and cough reflex. Integrated
Marcel Veternik, Lukas Martvon, Jakub Misek, Michal Simera, Ivan Poliacek   +4 more
doaj   +1 more source

The physiological effects of slow breathing in the healthy human

Breathe, 2017
Slow breathing practices have been adopted in the modern world across the globe due to their claimed health benefits. This has piqued the interest of researchers and clinicians who have initiated investigations into the physiological (and psychological ...
M. Russo, Danielle M. Santarelli, D. O'Rourke   +2 more
semanticscholar   +1 more source