Results 251 to 260 of about 610,465 (350)

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

open access: yesAdvanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu   +18 more
wiley   +1 more source

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

open access: yesAdvanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang   +11 more
wiley   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

open access: yesAdvanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun   +15 more
wiley   +1 more source

Thinned and Welded Silver Nanowires for Intelligent Pressure and Humidity Sensing Enabled by Machine Learning

open access: yesAdvanced Science, EarlyView.
Thinned and welded silver nanowires are prepared by selectively engineering their morphology and structure. The resulting films show enhanced optical, electrical, thermal, and mechanical properties. By incorporating machine learning, the developed pressure and humidity sensors are able to accurately identify finger pressing behaviors, monitor human ...
Jiajun Fan   +14 more
wiley   +1 more source

MXene/Carboxymethyl Chitosan Moisture Responsive Soft Actuator with Diode‐Like Actuation for Versatile Applications Driven by Human Metabolism

open access: yesAdvanced Science, EarlyView.
A MXene‐based actuator with gradient thickness is fabricated by a novel and simple vacuum‐assisted “tilt‐filtration” approach. The actuator exhibits a “diode‐like” controllable unidirectional deformation behavior under moisture gradient, and its deformation direction is strictly correlated to its thickness gradient direction and moisture source ...
Liangliang Xu   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy