Results 61 to 70 of about 2,339 (265)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A novel discontinuous-Galerkin deterministic neutronics model for fusion applications: workflow for stellarator reactor design studies

Nuclear Fusion
Stellarator reactor design and optimization requires quick and accurate neutronic simulations for obtaining tritium breeding ratio, coil neutron flux, and volumetric neutron heating.
Timo J. Bogaarts, Felix Warmer
doaj   +1 more source

Structural assessment of the gripper interlock of the DEMO breeding blanket transporter. [PDF]

Heliyon, 2023
Mozzillo R, Bachmann C, Fanelli P, Janeschitz G, Steinbacher T.   +4 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Assessing the risk of proliferation via fissile breeding in ARC-class fusion power plants

Nuclear Fusion
Construction of a nuclear weapon requires access to kilogram-scale quantities of fissile material, which can be bred from fertile material like U-238 and Th-232 via neutron capture. Future fusion power plants, with total neutron source rates in excess of
John L. Ball, Ethan E. Peterson, R. Scott Kemp, Sara E. Ferry   +3 more
doaj   +1 more source

Numerical design of the Seed-Blanket Unit for the thorium nuclear fuel cycle

E3S Web of Conferences, 2016
In the paper we present the Monte Carlo modelling by the means of the Monte Carlo Continuous Energy Burn-up Code of the 17x17 Pressurized Water Reactor fuel assembly designed according to the Radkowsky Thorium Fuel concept.
Oettingen Mikołaj, Skolik Katarzyna
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Fatigue lifetime prediction and reliability assessment for fusion blankets under pulsed operational loading

Nuclear Fusion
The breeding blanket is a critical component of magnetic confinement fusion reactors. The reliability, availability, maintainability, and inspectability (RAMI) of the blanket has been recognized as a major challenge on the pathway to commercial fusion ...
Qingzhu Liang, Xuebin Ma, Xiaoman Cheng, Lei Chen, Songlin Liu   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Development status of 30 MeV cyclotron-based neutron source in Korea [PDF]

EPJ Web of Conferences
KAERI has developed plasma heating systems and fusion engineering technologies such as blanket first wall and breeding blanket for nuclear fusion reactor development, as well as nuclear data production.
Lee Dong Won, Lee Kihyun, Jung Bongki, Lee Jongchul, Park Jeong Hoon, Kim Jongyul, Moon Myung Kook, Lee Chang Hee   +7 more
doaj   +1 more source