Results 61 to 70 of about 506,342 (292)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The future stability of upland blanket peat following historical erosion and recent re-vegetation [PDF]

, 2005
The importance of fluvial dissection in upland blanket peat erosion is well-established but knowledge of the significance of peatland gully system development is limited. This thesis investigates the stability of upland blanket peat in relation to recent
Clement, Sarah
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Breeding blanket mock-up testing in IFMIF-DONES

Nuclear Fusion
The fusion community is looking for solutions to qualify the breeding blankets (BB) before their final testing in DEMO. Thus, ambitious and attractive proposals, like the Volumetric Neutron Source, are being explored.
D. Rapisarda, P. Arena, F. Arranz, B. Brañas, F. Mota, M.I. Ortiz, A. Serikov, G. Zhou   +7 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Advancements in DEMO WCLL breeding blanket design and integration [PDF]

, 2017
The water-cooled lithium–lead breeding blanket is a candidate option for the European Demonstration Power Plant(DEMO) nuclear fusion reactor. This breeding blanket concept relies on the liquid lithium– lead as breeder–multiplier,pressurized water as ...
Di Maio, P. A. ., P. Arena, Caruso G., GIANNETTI, FABIO, Villari, R., Caruso, G., Giannetti F., A., Del Nevo, A., TASSONE, ALESSANDRO, Marinari, R., Bongiovi G., P. A. Di Maio, Tarallo A., Arena, P., Bongiovì, G., Di Maio P. A., F. Moro, Eboli M., A. Del Nevo, Tarallo, A., G. Mariano, A. Tassone, Tassone A., Mozzillo R., TARALLO, ANDREA, Martelli, E., Del Nevo, R. Villari, Di Gironimo, G., Di Gironimo G., Mariano, G., Del Nevo A., MOZZILLO, ROCCO, Moro F., R. Mozzillo, CARUSO, Gianfranco, G. Caruso, Di Maio, P. A., Mozzillo, R., F. Giannetti, Giannetti, F., Marinari R., Moro, F., M. Eboli, MARTELLI, EMANUELA, R. Marinari, Eboli, M., E. Martelli, Villari, S., Tassone, A., DI GIRONIMO, GIUSEPPE, Martelli E., Villari R., Mariano G., Arena P., G. Bongiovì, G. Di Gironimo, A. Tarallo   +58 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Impact of fusion neutrons on helium production in beryllium and tungsten, and tritium breeding in ITER and DEMO [PDF]

, 2014
The project studies blanket designs of ITER and DEMO for neutron shielding, helium production and tritium breeding. On the one hand, a comparison has been made between beryllium and tungsten as first wall materials.
Fernández Navarro, Alejandro
core