Results 81 to 90 of about 476,906 (298)

Three-dimensional model of DEMO-FNS facility considering neutronics and radiation shield problems

Heliyon, 2019
Recent neutronics studies of blankets for tokamak-based demonstration fusion neutron source (DEMO-FNS) showed a crucial influence of coolant composition on the transmutation rate of transuranic elements and tritium breeding in the system.
A.V. Zhirkin, B.V. Kuteev
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Data integration for decision making in wheat breeding [PDF]

, 2011
Plant breeding is a production process requiring the creation of germplasm through taking existing successful cultivars and crossing them with new parental lines with agronomic and quality attributes of interest.
Diepeveen, Dean
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Cross-section sensitivity of tritium breeding in fusion reactor blankets [PDF]

, 1973
ion; San Diego, California, USA (16 Apr 1974). The objective of the present study is the identification of crosssection uncertainties which might produce uncertainties of the order of several percent in the tritium breeding ratio in fusion reactor ...
Tobias, M., Steiner, D.
core   +1 more source

Numerical Investigation and Analytical Modeling of MHD Pressure Drop in Lead–Lithium Flows Within Rectangular Ducts Under Variable Magnetic Field for Nuclear Fusion Reactors

Journal of Nuclear Engineering
The breeding blanket is a key component of tokamaks, primarily responsible for extracting heat from fusion reactions and for tritium breeding, which is essential to ensure a fusion reactor’s fuel self-sufficiency.
Silvia Iannoni, Gianluca Camera, Marcello Iasiello, Nicola Bianco, Giuseppe Di Gironimo   +4 more
doaj   +1 more source

The effects of extended photoperiod and warmth on hair growth in ponies and horses at different times of year.

PLoS ONE, 2020
Photoperiod is considered the most dominant environmental cue allowing animals to anticipate and adapt to seasonal changes. In seasonally breeding mammals, changes in daylength alter pineal melatonin secretion and pituitary prolactin secretion.
Christiane O'Brien, Megan Ruth Darcy-Dunne, Barbara Anne Murphy   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source