Results 121 to 130 of about 24,051,771 (331)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Outcrossing rate of safflower (Carthamus tinctorius L.) genotypes under the agro climatic conditions of Northern Germany [PDF]

open access: yes, 2008
Safflower oil is considered to be one of the highest quality vegetable oils for human nutrition, containing up to 90% linoleic acid. The cultivation of safflower would enlarge the number of species to increase biodiversity and widen crop rotation.
Becker, Heiko C.   +2 more
core  

The plant immune system: From discovery to deployment

open access: yesCell
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change.
Jonathan D. G. Jones   +2 more
semanticscholar   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Plant Mating Systems Often Vary Widely Among Populations

open access: yesFrontiers in Ecology and Evolution, 2018
Most flowering plants are hermaphroditic, yet the proportion of seeds fertilized by self and outcross pollen varies widely among species, ranging from predominant self-fertilization to exclusive outcrossing.
Michael R. Whitehead   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Penentuan Sistem Penangkaran Rusa Timor (Rusa Timorensis De Blainville 1822) Berdasarkan Jatah Pemanenan Dan Ukuran Populasi Awal [PDF]

open access: yes, 2012
Harvest quota and population size could be used to determine deer captive breeding system. Development Center of Deer Captive Breeding Technology at Dramaga Research Forest (DRF) is one of captive breeding projected to be one of professional institution ...
Kartono, A. P. (Agus)   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Demographic performance of local sheep and goat breeds in two agro-ecological zones in Egypt [PDF]

open access: yes, 2019
Small breeders in Egypt raise locally adapted sheep and goats breeds, which have the ability to produce and reproduce under the prevailing harsh conditions.
Abdel-Sabour, T.   +7 more
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

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