Results 171 to 180 of about 169,122 (299)

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Phenotypic comparison of idiopathic epilepsy in English Springer Spaniels and Cocker Spaniels using a validated owner-completed questionnaire. [PDF]

Front Vet Sci
Dose JC, Matz MS, Harmas T, Hytönen M, Hakanen E, Lohi H, Parmentier T, Volk HA, Nessler JN, Bhatti SFM, De Risio L, Mandigers P, Ito D, James FMK, Jokinen TS, Ricketts S, Steffen F, Wielaender F, Eschenberg A, Fischer A, Tipold A.   +20 more
europepmc   +1 more source

Non‐Coding Transcripts From Diversified Members of IgLec Family Protect Antiviral Effectors From Viral miRNA

Advanced Science, EarlyView.
The IgLec gene family generates both protein‐coding antiviral effectors and non‐coding transcripts. Upon viral infection, non‐coding transcripts are preferentially targeted by viral miR‐N48, thereby buffering protein‐coding isoforms from repression. Depletion of these decoy transcripts compromises antiviral defense, revealing a non‐coding RNA‐mediated ...
Ying Huang, Rui Shen, Xin Huang, Gu‐Qin Ji, Jiang‐Feng Lan, Qian Ren   +5 more
wiley   +1 more source

Meta-analysis with batch-effect adjustment reveals breed-specific ruminal microbiome variation of beef cattle and its implications for meat quality and productivity. [PDF]

J Anim Sci Technol
Kang R, Yu C, Gwon Y, Lee S, Yang J, Jeong J, Kim G, Lee W, Jo W, Oh MG, Jang C, Tilahun M, Oh J, Park T.   +13 more
europepmc   +1 more source

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source

Evaluation of Two Commercial DNA-Based Breed Identification Tests for Pit Bull-Type Dogs in Taiwan: A Pilot Study. [PDF]

Animals (Basel)
Yang YY, Lee AN, Chen TC, Huang WH.
europepmc   +1 more source

Correction to “High‐Resolution Genomic Resources for Trait Mapping and Precision Breeding for Adzuki Bean (Vigna angularis)”

Advanced Science, EarlyView.
wiley   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Genomic Insights into Inbreeding, Population Structure, and Selection Signatures in Salem Black and Global Goat Breeds. [PDF]

Animals (Basel)
Akinsola OM, Muthusamy M, Chinnasamy AK, Ramasamy C, Pal P, Ramasamy S, Jeyakumar M, Opaluwa-Kuzayed IG, Thiruvenkadan AK, Peters SO.   +9 more
europepmc   +1 more source

Rhizodeposition Drives One Third of Belowground Carbon Input in Agroecosystems

Advanced Science, EarlyView.
This study quantifies photosynthesized C allocation in the plant–soil system across six crop types: barley, wheat, maize, rice, legumes and grasses. It reports C partitioning into shoot respiration, shoot‐C, root‐C, net rhizodeposition and root‐derived CO2, providing standardized percentage averages and GPP‐derived absolute values as a robust baseline ...
Zhengjun Yan, Yuan Wen, Jie Zhou, Yakov Kuzyakov, Damien Beillouin, Johannes Lehmann, Yadong Yang, Yiqi Luo, Pete Smith, Zhaohai Zeng, Huadong Zang   +10 more
wiley   +1 more source