Results 31 to 40 of about 80,737 (268)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Functional Insights into Genic Neighbourhood Organization of Helitron Transposons in Bos taurus Genomes [PDF]

Журнал Сибирского федерального университета: Серия Биология, 2017
Transposable elements (TEs) represent well-known factors of genomic variability and evolution. TEs are important providers of regulatory elements that are able to significantly influence the architecture and expression of the host genome. Currently, of a
Anna V. Babii, Svetlana N. Koval’chuk, Tat’iana T. Glazko, Valerii I. Glazko, Gleb I. Kosovskii   +4 more
doaj  

Physiological breeding

Current Opinion in Plant Biology, 2016
Physiological breeding crosses parents with different complex but complementary traits to achieve cumulative gene action for yield, while selecting progeny using remote sensing, possibly in combination with genomic selection. Physiological approaches have already demonstrated significant genetic gains in Australia and several developing countries of ...
Reynolds, Matthew, Langridge, Peter
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Single-cell RNA sequencing uncovers cellular heterogeneity of granulosa cells and provides a signature for follicular development in chicken

Poultry Science
Functional differentiation of the granulosa cell (GC) layer plays an essential role in follicular development and oocyte maturation in birds. However, despite the importance of GCs, heterogeneity within the granulosa layer across poultry species remains ...
Shigang Yu, Xuemei Shen, Gang Wang, Juan Liao, Jia Chen   +4 more
doaj   +1 more source

Microsatellite based genetic variation among the buffalo breed populations in Pakistan

Journal of Veterinary Research, 2017
Introduction: Eight microsatellite loci were used to define genetic diversity among five native water buffalo breeds in Pakistan.
Hussain Tanveer, Babar Masroor Ellahi, Ali Akhtar, Nadeem Asif, Rehman Zia Ur, Musthafa Muneeb M., Marikar Faiz MMT   +6 more
doaj   +1 more source

Estimation of genetic associations between reproduction and production traits based on a sire and dam line with common ancestry

Animal, 2009
Genetic parameters for survival, reproduction and production traits were estimated for a sire and dam line, originating from one Large White breed separated more than 25 years ago.
D.N.R.G. Kapell, C.J. Ashworth, G.A. Walling, A.B. Lawrence, S.A. Edwards, R. Roehe   +5 more
doaj   +1 more source

Heat tolerance in Mashona beef cows in semi-arid rangelands: does conformation matter?

Acta Agriculturae Slovenica, 2023
High temperatures and frequent heat waves raise concerns about heat stress in cattle in grass-based systems, especially in arid and semiarid areas. This study analysed the relationship between conformation traits and physiological parameters associated ...
Alphonce MATOPE, Titus Jairus ZINDOVE, Marshall DHLIWAYO, Michael CHIMONYO, Musavenga TIVAPASI   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source