Results 191 to 200 of about 143,220 (307)

Dimerization of human PARP15 is required for NAD+ binding and automodification

The FEBS Journal, EarlyView.
This study provides an integrated structural model of human PARP15. Biophysical, enzymatic, and cell‐based analyses identify the dimer as the active oligomeric state capable of binding the substrate NAD+. A co‐crystal structure with a non‐hydrolyzable substrate analog BAD reveals the molecular basis for the dimerization requirement.
Anna Tuovinen, Johan Pääkkönen, Mirko M. Maksimainen, Lea Hirschen, Heli I. Hentilä, Marie Tauscher, Bernhard Lüscher, Carlos Vela‐Rodríguez, Patricia Korn, Lari Lehtiö   +9 more
wiley   +1 more source

Heat-associated hyponatremia and its outcomes in very old inpatients in northern Germany. [PDF]

Z Gerontol Geriatr
Mader N, Muthers S, Albrecht K, Scharpenberg M, Kribben A, Herget-Rosenthal S.   +5 more
europepmc   +1 more source

Biocatalytic synthesis of S‐adenosyl‐l‐methionine analogues for allosteric activation of cystathionine‐β‐synthase

The FEBS Journal, EarlyView.
Cystathionine‐β‐synthase (CBS) helps remove harmful homocysteine and supports the production of protective sulfur‐containing molecules. Using its natural activator, S‐adenosyl‐l‐methionine, as a template, we designed and tested 15 analogues. Three activated and stabilized the enzyme, including the newly identified S‐2‐amino‐adenosyl‐l‐methionine. These
Dalibor Nakládal, Žaneta Zajacová, Rick Oerlemans, Jana Havlikova, Gabriel Zorkócy, Lukáš Kerti, Katarína Sujová, Adrian Lengyel, Zoë van der Gun, Christina Yoseif, Adrianus Cornelis van der Graaf, Guido Krenning, Ján Kyselovič, Vladimír Frecer, Matthew R. Groves, Zdenko Levarski, André Heeres, Rob H. Henning, Leo E. Deelman   +18 more
wiley   +1 more source

Gemeinsame Landesplanung Bremen/Niedersachsen wiederbelebt

Raumforschung und Raumordnung, 1992
Axel Priebs
doaj  

artec: Forschungszentrum Nachhaltigkeit an der Universität Bremen

Technikfolgenabschätzung – Theorie und Praxis, 2003
H. Lange
doaj   +1 more source

Micro-CT-Based Experimental Study on the 3D Structure-Electrical Conductivity Relationship of Metal-Coated Woven Fabrics. [PDF]

Materials (Basel)
Tokarska M, Puszkarz AK, Makówka M.
europepmc   +1 more source

Triple Oxygen Isotope Compositions of Isotopic Reference Waters: Implications for VSMOW‐Scale and VSMOW–SLAP‐Scale Δ′17O Calibration

Geostandards and Geoanalytical Research, EarlyView.
Key Points Triple oxygen isotope ratios of two primary (VSMOW, SLAP) and twelve secondary water isotopic reference materials were precisely measured using BrF5 fluorination‐IRMS. The measured Δ'17OVSMOW value for SLAP (34 ± 6 per meg) demonstrates that VSMOW‐SLAP normalisation ensures interlaboratory comparability, but introduces systematic offsets for
Ryoji Tanaka, Andreas Pack, Tyler B. Coplen   +2 more
wiley   +1 more source

Study protocol for evaluating integrated urban development plans: impacts on health, social equity, and environmental sustainability in Germany. [PDF]

BMC Public Health
Tönnies J, Krumreihn A, Stelzer F, Senck E, Bongers-Römer S, Stalling I, Gröne K, Bammann K, Köckler H, Bolte G.   +9 more
europepmc   +1 more source

Proteomic Analysis of Serum Extracellular Vesicles Revealed Fibulin‐3 as a Novel Predictive Biomarker for Hepatocellular Carcinoma in Patients With Chronic Hepatitis B

Hepatology Research, EarlyView.
We carried out proteomic analysis of serum extracellular vesicles to identify biomarkers predictive of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B receiving nucleos(t)ide analog therapy. Candidate proteins identified through proteomic analysis were subsequently quantified in serum by ELISA.
Emi Sometani, Kazuhiro Murai, Hayato Hikita, Jihyun Sung, Satoshi Muraoka, Hidenori Toyoda, Satoshi Tanaka, Takayuki Miyake, Shinji Kuriki, Kenji Fukumoto, Satoshi Shigeno, Yuta Myojin, Kazuki Maesaka, Kumiko Shirai, Yuki Makino, Yuki Tahata, Yoshinobu Saito, Takahiro Kodama, Ryotaro Sakamori, Jun Adachi, Tomomi Yamada, Tetsuo Takehara   +21 more
wiley   +1 more source

Rapid Clearance of microRNA-371a-3p: A Longitudinal Study of Serum Levels in Patients with Localized Testicular Germ Cell Tumors. [PDF]

Eur Urol Open Sci
Dieckmann KP, Niemzok T, Diesend J, Franke M, Klemke M, Harms A, Wülfing C, Wagener N, Belge G.   +8 more
europepmc   +1 more source