Results 71 to 80 of about 66,657 (200)
PARP-1 regulates DNA repair factor availability. [PDF]
, 2018 PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth +31 more
core +2 more sources
Integrated scFv identification and CAR T cell generation for AML targeting in vivo
International Journal of Cancer, Volume 158, Issue 4, Page 994-1007, 15 February 2026.What's new? Acute myeloid leukemia (AML) is a rapidly progressing blood cancer. Advancing chimeric antigen receptor (CAR) T cell therapies, particularly through rapid translation of single chain variable fragment (scFv) discovery into CAR constructs, may improve clinical outcomes, especially the development of patient individualized CAR T cells.
Yi Liu +13 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Introduction Sleep problems are common among cancer patients. The relationship between sleep disruption and clinical outcomes after colorectal cancer (CRC) diagnosis remains poorly understood. We investigated associations of sleep disruption with survival and recurrence in patients with CRC. Methods CRC patients with stages I–IV (N = 895) were
Anita R. Peoples +18 more
wiley +1 more source
Cisplatin-based chemotherapy of testicular cancer - Two decades after a major breakthrough [PDF]
, 2000 Two decades ago the introduction of cisplatin-based combination chemotherapy has dramatically improved the prognosis of patients with metastatic testicular cancer, At present 3 cycles of cisplatin, etoposide and bleomycin are considered as standard ...
Gerl, Arthur
core +1 more source
Head &Neck, Volume 48, Issue 2, Page 486-495, February 2026.ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) is a malignancy with poor prognosis and survival. While epidermal growth factor receptor (EGFR) is a known driver of HNSCC, EGFR inhibitors show limited efficacy as monotherapies, suggesting that effective combination therapies are needed.
Jiayu Wang +13 more
wiley +1 more source
Coexistence of Ovarian Mucinous Adeno Carcinoma and Benign Brenner Tumor: A Case Report
Gynecology Obstetrics & Reproductive Medicine, 2011 Mucinous ovarian tumors are known to coexist sometimes with Brenner tumors; however, in many of the cases in the literature, mucinous cystadenomas are seen to have been analyzed.
Özlem Seçilmiş Kerimoğlu +3 more
doaj
Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions [PDF]
, 2016 An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from ...
Churin, Yuri +7 more
core +1 more source
Enhanced Expression of IL32 mRNA in Skeletal Muscles in the Context of Head and Neck Carcinomas
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Cancer‐related sarcopenia (CRS) is a significant complication of head and neck carcinoma (HNC), characterised by muscle degeneration and poor clinical outcomes. Although various dietary and therapeutic interventions have been explored, most of them remain empirical, and the molecular mechanisms underlying CRS are not yet fully ...
Imane Baïche +17 more
wiley +1 more source
Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo. [PDF]
, 2014 Spores of some species of the strictly anaerobic bacteria Clostridium naturally target and partially lyse the hypoxic cores of tumors, which tend to be refractory to conventional therapies. The anti-tumor effect can be augmented by engineering strains to
Dubois, L +10 more
core +4 more sources
Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.Abstract A 6‐year‐old, mixed‐breed dog was referred for evaluation of a red, non‐painful right eye. Examination revealed a well‐circumscribed, lobulated, reddish mass in the anterior chamber, initially presumed to be a benign haematocyst. Despite the non‐aggressive appearance and lack of pain or inflammation, the mass demonstrated rapid enlargement ...
Lionel Sebbag, Nili Kahane, Havi Sarfaty
wiley +1 more source