Results 191 to 200 of about 1,215,022 (288)

DDX3 Regulates the Cap‐Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome

open access: yesAdvanced Science, EarlyView.
Japanese encephalitis virus (JEV) employs a cap‐independent (CI) translation strategy to evade host translational shutoff. During the shut‐off of host cellular canonical translation, DEAD‐box protein 3 (DDX3) bind to JEV UTRs to establish a closed‐loop architecture, and its interaction with poly(A)‐binding protein 1 (PABP1) to form DDX3/PABP1/eIF4G ...
Chenxi Li   +13 more
wiley   +1 more source

Enhanced Electrical Performance and Stretchability by Plasticizer‐Facilitated PEDOT:PSS Self‐Alignment

open access: yesAdvanced Science, EarlyView.
To advance stretchable electronics, understanding how organic plasticizers influence poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) morphology and conductivity remains crucial. A bilayer model with glycerol‐infused poly(vinyl alcohol) (PVA) substrates reveals that plasticizer diffusion reorganizes PEDOT and PSS, improving ...
Carla Volkert   +7 more
wiley   +1 more source

Active phase discovery in heterogeneous catalysis via topology-guided sampling and machine learning. [PDF]

open access: yesNat Commun
Zheng S   +10 more
europepmc   +1 more source

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

open access: yesAdvanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He   +15 more
wiley   +1 more source

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

open access: yesAdvanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz   +24 more
wiley   +1 more source

Toward High‐Performance Electrochemical Energy Storage Systems: A Case Study on Predicting Electrochemical Properties and Inverse Material Design of MXene‐Based Electrode Materials with Automated Machine Learning (AutoML)

open access: yesAdvanced Electronic Materials, EarlyView.
This study demonstrates PyCaret's AutoML framework for predicting the electrochemical and structural properties of MXene‐based electrodes, including intercalation voltage, capacity, and lattice constants. AutoML streamlines workflows, ranks key elemental descriptor, and enables inverse molecular formula prediction based on performance targets.
Berna Alemdag   +3 more
wiley   +1 more source

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