Results 41 to 50 of about 403,670 (301)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Church, Communication and Culture, 2020 The canonisation of John Henry Newman by Pope Francis in 2019 was an opportunity to communicate to a largely secular audience in Britain and the rest of the world the search for truth that inspired Newman’s life.
Jack Valero
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Turcology ResearchDuring his three terms as Prime Minister of Britain, Salisbury also served concurrently as Foreign Secretary, exerting decisive influence over foreign policy.
Serdar Bay
doaj +1 more source
A Fifth-Century «Gallic Empire»: Hispania as Part of Constantine III’s Usurpation
Studia Historica: Historia Antigua, 2020 This paper follows the route of the usurper Constantine III since he was made emperor by the troops in Britain in 407 A. D., until his defeat under the magister militum Constantius.
María FERNÁNDEZ PORTAENCASA
doaj +1 more source
Economica, 1986 Male unemployment in Britain has risen from around 2 per cent in the 1950s to around 17 per cent in 1985 (see Figure 1). (The figures are for male unemployment because there is no consistent series for women.1) Even more remarkably, unemployment has fallen in only three years out of the last twenty (1973, 1978 and 1979).
Layard, Richard, Nickell, Stephen
openaire +4 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A sociolinguistic ecology of colonial Britain
, 2019 In this chapter, I look at the sociolinguistic context that colonists, settlers, pioneers, convicts, and others left when embarking on their travels. It does not therefore look at the migrants themselves or their linguistic profiles per se but at the ...
Britain, David, David Britain
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source