Results 231 to 240 of about 2,198,254 (310)

CAFs‐mediated histone lactylation reprograms cholesterol metabolism in colorectal cancer to drive CD8+ T cell immunosuppression

The Journal of Pathology, EarlyView.
Abstract The progression of colorectal cancer (CRC) is critically regulated by cancer‐associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through ...
Huachi Li, Jun Hu, Lei Huang, Zihao Wang, Haoran Tao, Feng Cao, Min Xie   +6 more
wiley   +1 more source

CSF1R+ Macrophages and Osteoclasts Are Essential for Limb Bone Development During Embryogenesis. [PDF]

J Dev Biol
Ma F, Zhou RRJ, Rosin M, Rosin JM.
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Rooftop Breeding Does Not Consistently Explain Variation in Yolk Testosterone in Herring Gulls. [PDF]

Ecol Evol
Van Malderen J, Lens L, Verbruggen F, Stienen EWM, Müller W.   +4 more
europepmc   +1 more source

Repeated Pleistocene Permafrost Episodes in the Western Pannonian Basin

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT Concerning the study of past periglacial processes, the Pannonian Basin is a key area as it contains the southernmost frost polygons found in Central Europe. The presence or absence of permafrost is still, however, a matter of debate, and data on the timing of frost action are also scarce.
Krisztina Sebe, Ágnes Novothny, Gergely Surányi, Barbara Varga, László Fodor, Gábor Csillag   +5 more
wiley   +1 more source

Between-species contagion drives HPAI transmission and mass mortality in seabirds. [PDF]

J Anim Ecol
Matthiopoulos J, Votier S, Wanless S, Cunningham E, Lane JV, Jeglinski JWE.   +5 more
europepmc   +1 more source

Looking backward to move forward: Enhancing metadata in scientific collections through interdisciplinary collaboration

PLANTS, PEOPLE, PLANET, EarlyView.
Early modern herbaria house important and useful data on historic environments. However, their contents are often inhospitable to scientific use. Despite this challenge, once their contents have been deciphered, such specimens present novel research opportunities.
Madeline E. White, Stephen A. Harris
wiley   +1 more source

From settler gardens to digital naturalists: human aesthetic preferences and land use changes facilitate the biogeographical expansion of a wild plant–virus interaction

PLANTS, PEOPLE, PLANET, EarlyView.
Anthropogenic facilitation of wild plants based on aesthetic preferences for particular traits can change the biogeography and ecology of natural communities. We use a mixed‐methods socioecological approach to characterize the ways in which humans interact with a common, widely distributed plant and a generalist viral symbiont that induces an ...
Elizabeth M. Lombardi, Jasmine S. Peters, Juan Pablo Jordán, Alison G. Power   +3 more
wiley   +1 more source

Relapsing facial pemphigus vegetans associated with chronic intranasal cocaine use. [PDF]

JAAD Case Rep
Shin W, Haber RM, Hunter C, Kurwa HA, Nurmohamed S, Robertson LH.   +5 more
europepmc   +1 more source

Needle in a haystack: Holocene history of European larch in Central Europe revisited

PLANTS, PEOPLE, PLANET, EarlyView.
Defining nativity of species is crucial for their management. However, this is a complex task, especially for species that have been used and spread by humans for a long time. We combined paleoecological records with extensive genetic data to investigate the Holocene history of European larch—a common and economically important tree species in Central ...
Martin Prach, Petr Pokorný, Kristýna Hošková, Daniel Vondrák, Pavel Bednář, Jindřich Prach, Jana Hanzal Šedivá, Hana Drahošová, Kateřina Podrábská, Přemysl Bobek, Jan Smyčka, Tomáš Fér   +11 more
wiley   +1 more source