Results 241 to 250 of about 15,942,859 (313)

A novel minimally humanized mouse model of aniridia for preclinical evaluation of CRISPR gene editing strategies. [PDF]

Front Genome Ed
Mirjalili Mohanna SZ, Korecki AJ, Kazemian P, Lengyell TC, Adair BA, Leavitt BR, Simpson EM.   +6 more
europepmc   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

Transforming multimorbidity care: Organizational barriers and provider behaviour in type 2 diabetes and cardiovascular disease. [PDF]

Br J Health Psychol
Brown JE, Umeh FK, Lotto R, Madroumi R, Jones I, Rashidi A, Newson L.   +6 more
europepmc   +1 more source

Bacterial Cellulose Membranes for Dye Removal: Adsorption Behavior, Thermodynamics, Regeneration, and Performance in Simulated Wastewater. [PDF]

Biopolymers
Aranda FL, Oropesa Y, Gatica EP, Sánchez J, Oñate A, Meléndrez MF, Rojas O, Palacio DA.   +7 more
europepmc   +1 more source

Impact of the pancreatic enzyme replacement therapy (PERT) shortage on prescribing in England: Analysis of national data

British Journal of Clinical Pharmacology, EarlyView.
Aim Pancreatic enzyme replacement therapy (PERT) is essential for the management of pancreatic exocrine insufficiency. Since June 2023, the United Kingdom has been affected by a global shortage of PERT. We investigated the impact of this shortage on national prescribing trends for Creon, Nutrizym, Pancrex and Pangrol.
Teena S. Varghese, Mary E. Phillips, Louis Fisher, Helen Fitt, Adam Frampton, Christopher Wood, Agnieszka Lemanska   +6 more
wiley   +1 more source

Factors associated with loneliness and social capital in a large volunteer sample of adults in England. [PDF]

BMC Glob Public Health
El-Osta A, Al-Ammouri M, Alaa A, Altalib S, Tristán-López A, Majeed A.   +5 more
europepmc   +1 more source

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire, Andrew T. Lambarth, Ayesha Saleem, Daniel R. Burrage   +3 more
wiley   +1 more source

Open-source automated insulin delivery shows comparable glycemic outcomes to a commercial hybrid closed-loop system in real-world type 1 pediatric diabetes care: a retrospective cohort study from British Columbia, Canada. [PDF]

Pediatr Diabetes
Hejla D, Hawke K, Borovoi L, Elliott T, Panagiotopoulos C.   +4 more
europepmc   +1 more source

The parental intestinal microbiome modulates systemic and local glucocorticoid levels in neonatal mice. [PDF]

PLoS One
Hamden JE, Ainsworth-Cruickshank G, Gray KM, Ye J, Kachkovski GV, Forys BJ, Sie C, Silva JAFD, Salehzadeh M, Ghosh S, Harder KK, Soma KK.   +11 more
europepmc   +1 more source

Health economic considerations for pharmacogenomic services in the United Kingdom: The Centre for Excellence in Regulatory Science and Innovation in Pharmacogenomics

British Journal of Clinical Pharmacology, EarlyView.
Dyfrig A. Hughes, Henry Fong, Grace Hampson, Catrin O. Plumpton, Chris Sampson   +4 more
wiley   +1 more source