Results 231 to 240 of about 7,144,441 (302)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Author Correction: Building new hydrography and virtual watersheds to conserve freshwater fisheries. [PDF]

Sci Rep
Benda L, Miller D, Leppi JC, Romey B, Andras K.   +4 more
europepmc   +1 more source

Enemy's arsenal backfires: pathogen proteases detonate broad-spectrum plant immunity via engineered NLRs. [PDF]

Stress Biol
Liu S, Jing Y, Chen J.
europepmc   +1 more source

Differential Transdiagnostic Relevance of Early Maladaptive Schemas Across Personality Traits and Psychopathological Symptoms. [PDF]

Personal Ment Health
Major J, Matuz A, Gács B, Birkás B.
europepmc   +1 more source

Antibiotic Prophylaxis Strategies and Surgical Site Infections in Colorectal Surgery: A Systematic Review and Network Meta-Analysis.

JAMA Netw Open
Motaghi S, Karam SG, Mulazzani F, Mirzayeh Fashami F, Buchan TA, Ibrahim S, Moradi Falah Langeroodi S, Khademioore S, Couban RJ, Mbuagbaw L, Mertz D, Loeb M.   +11 more
europepmc   +1 more source

Integrating Precision Sepsis Risk Stratification Into Systems-Based Antimicrobial Stewardship. [PDF]

Open Forum Infect Dis
Ford JS, Nemati S, Gross B, Malhotra A, Wardi G.   +4 more
europepmc   +1 more source

The broad societal value of pembrolizumab for women's cancer in Canada. [PDF]

Future Oncol
Brook E, Patterson K, Wijenayake N, Madin-Warburton M, Mishkin K, Meilleur MC, Davies A, Young K.   +7 more
europepmc   +1 more source