Results 21 to 30 of about 7,144,441 (302)

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

Nature Communications, 2020
Large-scale screens of chemical and genetic vulnerabilities in cancer are typically limited to simple readouts of cell viability. Here, the authors develop a method for profiling post-perturbation transcriptional responses across large pools of cancer ...
James M. McFarland, Brenton R. Paolella, Allison Warren, Kathryn Geiger-Schuller, Tsukasa Shibue, Michael Rothberg, Olena Kuksenko, William N. Colgan, Andrew Jones, Emily Chambers, Danielle Dionne, Samantha Bender, Brian M. Wolpin, Mahmoud Ghandi, Itay Tirosh, Orit Rozenblatt-Rosen, Jennifer A. Roth, Todd R. Golub, Aviv Regev, Andrew J. Aguirre, Francisca Vazquez, Aviad Tsherniak   +21 more
doaj   +1 more source

Global computational alignment of tumor and cell line transcriptional profiles

Nature Communications, 2021
The determination of whether cancer cell lines recapitulate the molecular features of corresponding patient tumours remains essential for the selection of appropriate cell line models for preclinical studies.
Allison Warren, Yejia Chen, Andrew Jones, Tsukasa Shibue, William C. Hahn, Jesse S. Boehm, Francisca Vazquez, Aviad Tsherniak, James M. McFarland   +8 more
doaj   +1 more source

Organisational approaches to the 'professionalisation' agenda: planning the provision of the new ITE qualifications for the FE sector

Teaching in Lifelong Learning: A Journal to Inform and Improve Practice, 2010
Situated within the context of policy change in the Lifelong Learning Sector, this article is based on the LONCETT (London Centre for Excellence in Teacher Training) research strand exploring organisational responses to policy challenges and the impacts ...
Broad, Janet
doaj   +1 more source

Making Choices: "Dangerously Female" Rereading in Sula

Anuario de Letras Modernas, 2008
Making Choices: "Dangerously Female" Rereading in ...
Charlotte Broad
doaj   +1 more source

Systematic profiling of conditional degron tag technologies for target validation studies

Nature Communications, 2022
Conditional Degron Tags are a valuable tool to validate and study novel therapeutic targets. Here, the authors compared 5 orthogonal tags across 16 unique proteins and provide a panel of vectors for users to systematically screen the tags with their own ...
Daniel P. Bondeson, Zachary Mullin-Bernstein, Sydney Oliver, Thomas A. Skipper, Thomas C. Atack, Nolan Bick, Meilani Ching, Andrew A. Guirguis, Jason Kwon, Carly Langan, Dylan Millson, Brenton R. Paolella, Kevin Tran, Sarah J. Wie, Francisca Vazquez, Zuzana Tothova, Todd R. Golub, William R. Sellers, Alessandra Ianari   +18 more
doaj   +1 more source

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

Nature Communications, 2020
While genome-wide association studies have yielded thousands of trait-associated loci, identifying causal variants remains challenging. Here, the authors perform seven genomics assays in various cell types to prioritize genetic variants in the TNFAIP3 ...
John P. Ray, Carl G. de Boer, Charles P. Fulco, Caleb A. Lareau, Masahiro Kanai, Jacob C. Ulirsch, Ryan Tewhey, Leif S. Ludwig, Steven K. Reilly, Drew T. Bergman, Jesse M. Engreitz, Robbyn Issner, Hilary K. Finucane, Eric S. Lander, Aviv Regev, Nir Hacohen   +15 more
doaj   +1 more source

Broad and deep [PDF]

Canadian Medical Association Journal, 2015
On a July morning, I sat, notebook in hand, with three junior medical students, sweat trickling in our hairlines. The heat was oppressive under the plastic tarp that served as a roof on this makeshift kitchen on the banks of the Bagmati River in Kathmandu.
openaire   +2 more sources

The genome sequence of the Small Ranunculus, Hecatera dysodea (Denis & Schiffermüller, 1775) [version 1; peer review: 2 approved]

Wellcome Open Research, 2023
We present a genome assembly from an individual female Hecatera dysodea (the Small Ranunculus; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence is 640.9 megabases in span.
Gavin R. Broad
doaj   +1 more source

A new, endemic genus of Anomaloninae (Hymenoptera, Ichneumonidae) from St Helena [PDF]

, 2014
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Broad, G
core   +2 more sources

The genome sequence of the dotted bee-fly, Bombylius discolor (Mikan, 1796) [version 1; peer review: 2 approved]

Wellcome Open Research, 2022
We present a genome assembly from an individual female Bombylius discolor (the dotted bee-fly; Arthropoda; Insecta; Diptera; Bombyliidae). The genome sequence is 280 megabases in span.
Gavin R. Broad
doaj   +1 more source