Results 191 to 200 of about 12,935 (248)

Copper-Photoredox-Catalyzed C(sp³)-C(sp³) Reductive Cross-Coupling of Alkyl Bromides with BCP-Thianthrenium Reagents. [PDF]

Angew Chem Int Ed Engl
Pandit S, Ritter T.
europepmc   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Revitalizing reformatsky reagent for catalyst-free direct alkylation with unactivated alkyl halides. [PDF]

Nat Commun
Meng L, Li Z, Zhang T, Xu Y, Li Y, Wu B, Shen Q.   +6 more
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Applying Active Learning toward Building a Generalizable Model for Ni-Photoredox Cross-Electrophile Coupling of Aryl and Alkyl Bromides. [PDF]

J Am Chem Soc
Souza LW, Ricke ND, Chaffin BC, Fortunato ME, Jiang S, Soylu C, Caya TC, Lau SH, Wieser KA, Doyle AG, Tan KL.   +10 more
europepmc   +1 more source

Multimodal Optical Imaging and Modulation with Simultaneous Electrophysiology Through Smart Dura in Non‐Human Primates

Advanced Science, EarlyView.
This study demonstrates multimodal integration in non‐human primates, combining large‐scale, high‐density electrophysiology using Smart Dura with optical techniques such as multiphoton imaging (MPI), photothrombotic lesioning, optical coherence tomography angiography (OCTA), wide‐field intrinsic signal optical imaging (ISOI), and optogenetics.
Nari Hong, Sergio Montalvo Vargo, Gaku Hatanaka, Zhaoyu Gong, Noah Stanis, Jasmine Zhou, Tiphaine Belloir, Ruikang K. Wang, Wyeth Bair, Maysamreza Chamanzar, Azadeh Yazdan‐Shahmorad   +10 more
wiley   +1 more source

An Eco-friendly Approach to C-H Bond Activation through Microwave Irradiation Employing Synthesized Palladium-PEPPSI-NHC Complexes. [PDF]

ACS Omega
Slimani I, Özdemir İ, Gürbüz N, Alıcı B, Arslan NB, Özdemir N.   +5 more
europepmc   +1 more source

Design and Characterization of DX‐Tile DNA Nanostar‐Based Hydrogels

Advanced Science, EarlyView.
In this study, the authors demonstrated that DNA DX‐tile‐based multi‐arm motifs can be used to assemble pure DNA hydrogels, offering greater design flexibility and enhanced control over their mechanical properties and functionalization capabilities compared to single duplex‐based DNA hydrogels.
Dylan V. Scarton, Alessandra B. Coogan, Peter M. Touma, Eray O. Tulun, Katie A. Harrison, Jack Buchen, Richard C. Steiner, Christopher R. Fellin, Hunter G. Mason, Chih‐Hsiang Hu, Sally Farag, Xiaoning Yuan, Shailly Jariwala, Remi Veneziano   +13 more
wiley   +1 more source

Coordination-Accelerated Catalysis in the Heck Reaction Using N-H <i>N</i>-Heterocyclic Carbene Pd Complexes. [PDF]

J Org Chem
Harper AP, Larson AJS, Brown LM, Owens RN, Noble KL, Villarreal-Quiroga GH, Michaelis DJ.   +6 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source