Results 41 to 50 of about 868 (153)

(Ph3P)4C4P4: Effect of substitution on the Oligomerization of carbon phosphide radicals

ChemistryEurope, Volume 3, Issue 1, January 13, 2025.
In contrast to P,N phases, the respective P,C phases are relatively underexplored. In this work, the synthetic access to a phosphine‐stabilized P4C4 cage compound is described. This species originates from the dimerization of a fleeting intermediate, namely a phosphine‐substituted four‐membered C2P2 biradicaloid. This intermediate could be trapped with
Moritz Scharnhölz, Jose Juan Gamboa Carballo, Nils Trapp, Rene Verel, Peter Coburger, Hansjörg Grützmacher   +5 more
wiley   +1 more source

Structure‐Based Design of Ultrapotent Tricyclic Ligands for FK506‐Binding Proteins

Chemistry – A European Journal, Volume 30, Issue 45, August 12, 2024.
A novel rigid, sp3‐rich tricyclic scaffold has been designed as a module for the development of FKBP small molecule ligands and molecular glues. Structure‐based design enabled the synthesized scaffold to precisely lock all functional groups for the optimal interaction with the protein target.
Patryk Krajczy, Christian Meyners, Maximilian L. Repity, Felix Hausch   +3 more
wiley   +1 more source

Multifunctional Fluoropolymer‐Engineered Magnetic Nanoparticles to Facilitate Blood‐Brain Barrier Penetration and Effective Gene Silencing in Medulloblastoma

Advanced Science, Volume 11, Issue 25, July 3, 2024.
Medulloblastoma is the most common pediatric brain malignancy. Here, multifunctional theranostic nanoparticles capable of 1)blood‐brain barrier penetration, 2) contrast enhancement of brain tumors (magnetic resonance imaging), and 3) superb short interference RNA delivery is presented in vitro and in vivo (orthotopic mouse model).
Helen Forgham, Jiayuan Zhu, Xumin Huang, Cheng Zhang, Heather Biggs, Liwei Liu, Yi Cheng Wang, Nicholas Fletcher, James Humphries, Gary Cowin, Karine Mardon, Maria Kavallaris, Kristofer Thurecht, Thomas P. Davis, Ruirui Qiao   +14 more
wiley   +1 more source

Fluorescent indicator dyes for calcium ions [PDF]

, 1986
The present invention discloses a new class of highly fluorescent indicator dyes that are specific for calcium ions. The new fluorescent indicator dyes combine a stilbene-type fluorophore with a tetracarboxylate parent Ca.sup.2+ chelating compound having
Grynkiewicz, Grzegorz, Tsien, Roger Y.
core   +1 more source

Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS‐STING Signaling

Advanced Science, Volume 11, Issue 20, May 28, 2024.
ENPP1 proteins are secreted by various tumor cells to the extracellular space via the exosomes and ENPP1 highly enriched in these exosomes. To evade immune surveillance, tumor exosomal ENPP1 can effectively hydrolyze extracellular 2′3′‐cGAMP or 2′3′‐cGAMP bound to LL‐37 (an effective transporter of 2′3′‐cGAMP) to inhibit cGAS‐STING pathway in immune ...
Yu An, Jinchao Zhu, Qihui Xie, Jianzhou Feng, Yanli Gong, Qian Fan, Jiao Cao, Zhi Huang, Weixiong Shi, Qingyuan Lin, Lingling Wu, Chaoyong Yang, Tianhai Ji   +12 more
wiley   +1 more source

Fluorinated Benzylphosphonic Acid Derivatives for Work Function Modification [PDF]

, 2014
Methodology for the synthesis of polyfluorinated biphenyl benzylphosphonic acids was developed and various highly fluorinated phosphonic acid derivatives may be synthesised from the corresponding fluorobenzene system.
ABRAHAM, FFION
core  

Phosphonium‐substituted Diphosphaindenylide (PPI): Exploration of Biradical Character and Ligand Properties

Chemistry – A European Journal, Volume 30, Issue 7, February 1, 2024.
The synthesis of a phosphonium‐substituted diphosphaindenylide, PPI, is reported. Introduction of two P atoms to the indenyl core results in considerable biradical character. Moreover, the ligand properties of PPI are investigated using a chromium tricarbonyl complex as model compound.
Peter Coburger, David Zuber, Clara Schweinzer, Moritz Scharnhölz   +3 more
wiley   +1 more source

Design and synthesis of probes for detection of protein-protein interaction and RNA localization [PDF]

, 2005
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.Includes bibliographical references.The use of the ketone biotin - benzophenone-biotin hydrazide system for detecting the formation of cyan fluorescent protein and NF-kappaB ...
Ryan, Jeremy Adam
core  

Self-Assembled Monolayer with Phenothiazine Derivatives [PDF]

, 2022
Department of ChemistryPower conversion efficiency (PCE) of perovskite solar cells (PSCs) reveals substantial improvement since 2009, because of optimized perovskite composition and the material development for a charge transport layer (CTL).
Park, Keun Hyeong
core  

One‐Pot Synthesis of Bioinspired Peptide‐Decorated Apatite Nanoparticles for Nanomedicine

Small, Volume 20, Issue 8, February 22, 2024.
Bio‐inspired peptide‐phosphate calcium apatite nanomaterials are obtained by one‐pot co‐precipitation of phosphonated polyethylene glycol‐peptide conjugates. Monomodal colloidal suspension is stabilized by the peptide corona which dictates the size of the particles and anchors through the phosphonate end group.
Mathilde Guérin, Aurélien Lebrun, Liisa Kuhn, Thierry Azaïs, Guillaume Laurent, Olivier Marsan, Christophe Drouet, Gilles Subra   +7 more
wiley   +1 more source