Results 131 to 140 of about 65,324 (305)

Changes in mRNA in left mainstem bronchi and in peripheral lung.

, 2018
Changes in mRNA in left mainstem bronchi and in peripheral lung.
T. Brett Kothe (5513738), Masatoshi Saito (498633), Emily Royse (3146850), Noah H. Hillman (556724), Matthew W. Kemp (320771), Gabrielle C. Musk (815006), Alan H. Jobe (320777), Haruo Usuda (815002)   +7 more
core   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Maximum relaxation (Emax) and potency (log EC50)observed with non-selective T2R agonists on human bronchi.

, 2016
Maximum relaxation (Emax) and potency (log EC50)observed with non-selective T2R agonists on human bronchi.
Miguel Armengot (300875), Desamparados Compañ (3207489), Julio Cortijo (300879), Celia Sanz (3207486), Esteban Morcillo (772597), Amparo Ortiz (3207495), Jose Luis Ortiz (3207492), Javier Milara (381748)   +7 more
core   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Attenuation of contractions to acetylcholine in canine bronchi by an endogenous nitric oxide-like substance

, 1993
1. The involvement was assessed of an endogenous nitric oxide-like substance in contractions of canine bronchi to acetylcholine. 2. Canine third order bronchial rings, in some of which the epithelium was removed mechanically, were suspended in organ ...
Gao, Y, Paul M. Vanhoutte, Yuansheng Gao, Vanhoutte, PM   +3 more
core   +1 more source

Lysosome‐Targeted Squaramide Anion Transporters

Chemistry – A European Journal, EarlyView.
Lysosome‐targeted squaramide anion transporters elicit different biological effects depending on the targeting group employed. ABSTRACT Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines.
Elba Feo, Edward York, Anthony Thai, William G. Ryder, Daniel A. McNaughton, Philip A. Gale   +5 more
wiley   +1 more source

Laryngotracheobronchitis due to Candida albicans in a Patient Admitted to the Intensive Care Unit: A Case Report

Respirology Case Reports
Several studies have identified Candida albicans as the predominant fungal pathogen involved in respiratory infections. Candida laryngotracheobronchitis is a rare but serious condition, typically observed in immunocompromised patients with predisposing ...
Maura Silva, Cristina Mendes, Kátia Diogo, João Silva, Margarete Arrais   +4 more
doaj   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

Radiological phenotyping bronchiectasis in the highlights of bronchiectasis radiologically indexed computed tomography score

Egyptian Journal of Chest Disease and Tuberculosis
Irreversible dilatation of airways, known as bronchiectasis is a significant global health issue with a wide range of clinical presentations and an extensive list of etiologies.
Saika Amreen, Waseem Y. Kawoosa, Mohd Y. Kawoosa, Aqib Rasool   +3 more
doaj   +1 more source