Results 251 to 260 of about 113,667 (333)

Advantage of Sleeve Right Lower Lobectomy for Lung Cancer in COPD Patients: A Case Series. [PDF]

open access: yesThorac Cancer
Harata Y   +7 more
europepmc   +1 more source

Association of autoimmune diseases with biologic agents targeting type 2 immunity: An observational study using a claims database

open access: yesRheumatology &Autoimmunity, EarlyView.
This observational study assessed the association between anti‐type 2 biologic agents and the occurrence of autoimmune diseases using a large real‐world claims database. Anti‐IL‐5 and anti‐IgE therapies were associated with an increased occurrence of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE ...
Shoichiro Inokuchi
wiley   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

open access: yesRespirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota   +17 more
wiley   +1 more source

Body Composition and Muscle Function in Bronchiectasis: A Comparative Longitudinal Study

open access: yesRespirology, EarlyView.
We compared body composition and muscle function in adults with bronchiectasis versus controls and assessed if leg strength estimates 1‐year outcomes. Patients with bronchiectasis had lower muscle mass, bone density, and leg strength. Reduced leg strength is associated with worse dyspnoea, quality of life, and functional capacity, highlighting the need
Joice Mara de Oliveira   +7 more
wiley   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min   +3 more
wiley   +1 more source

Variation on Toxic and Inflammatory Potential of Coal Smoke of Different Sources From a Region With High Lung Cancer Risk

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Excess lung cancer risk in Xuanwei and Fuyuan, China, has been attributed to household air pollution from use of a locally sourced smoky (bituminous) coal. However, the carcinogenic mechanisms remain unclear. Given the important role of inflammation in lung cancer development, this study compared the proinflammatory potentials of the ...
Yongliang Zhang   +10 more
wiley   +1 more source

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