Aging Cell, Volume 24, Issue 4, April 2025.Tert knock‐in (TertKI) mice harboring the EF1α‐Tert gene in the Rosa26 locus displayed heightened telomerase activity, elongated telomeres, and extended lifespan. TertKI mice displayed enhanced wound healing and exhibited resistance to the progression of colitis.
Tian‐Yi Zhu +9 more
wiley +1 more source
A Case of Pulmonary Bulla Volume Reduction by Transbronchial Puncture Under Electromagnetic Navigation Platform Combined With O-Arm CT Guidance. [PDF]
Int J Chron Obstruct Pulmon DisZhu J, Xu X, Wang R, Li Z, Wang Y, Hu Y.
europepmc +1 more source
Aging Cell, Volume 24, Issue 5, May 2025.During spread of Streptococcus pneumoniae from the lung to the bloodstream, the pneumococcal pore‐forming toxin pneumolysin (PLY) disrupts apical junction complexes (AJCs) and triggers the transmigration of polymorphonuclear leukocytes (PMNs), which secrete tissue‐destructive neutrophil elastase.
Shuying Xu +4 more
wiley +1 more source
Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor ratio > 0.5. [PDF]
Front OncolLi D +6 more
europepmc +1 more source
Aging and Cancer—Inextricably Linked Across the Lifespan
Aging Cell, Volume 24, Issue 4, April 2025.Aging (as old man wind) alters the trajectory of cancer (dangerous seas) through changes in the immune system and metabolism (among many others), leading to altered cancer epidemiology, pathogenesis, and therapeutic responses, as represented by the research areas (boats)—artwork by Michael DeGregori.
James DeGregori +2 more
wiley +1 more source
Bronchiolitis obliterans due to toxic epidermal necrolysis with structural evaluation using computed tomography bronchography: A case report. [PDF]
Acute Med SurgKudo H, Katsuta K, Kushimoto S.
europepmc +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source
Serovar and multilocus sequence typing analysis of Pasteurella multocida from diseased pigs in Taiwan. [PDF]
BMC Vet ResWu CF +5 more
europepmc +1 more source
The impacts of e‐cigarette flavours: An overview of systematic reviews
Addiction, EarlyView.Abstract Background and Aims E‐cigarette flavours have the potential to impact the appeal, harms and use of e‐cigarettes and combustible tobacco. Systematic reviews have synthesised evidence on their impacts but have always focused on specific outcomes or populations.
Jonathan Livingstone‐Banks +7 more
wiley +1 more source