Results 81 to 90 of about 5,063 (242)

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Overcoming EGFR‐Mediated Dendritic Cell Dysfunction to Enhance Anti‐tumor Immunity in EGFR‐Mutant NSCLC by Precisely Targeting CD73 With pH‐responsive Nanocarriers

Advanced Science, EarlyView.
EGFR mutations drive ERK/c‐Jun–mediated transcriptional activation of CD73, elevating adenosine levels and fostering an immunosuppressive TME by impairing DC maturation and CD8⁺ T cell priming. The pH‐responsive nanodrug F127ZIF‐8AB680 selectively inhibits CD73, normalizes adenosine metabolism, and re‐establishes effective anti‐tumor immunity ...
Xiaoling Shang, Xudong Geng, Zixu Wang, Shumin Yuan, Shanshan Ding, Ni Liu, Xinchun Ma, Xuan Sun, Huimin Wang, Ying Sun, Xun Qu, Guangwen Ren, Yong Qiang Li, Xiuwen Wang, Yanguo Liu   +14 more
wiley   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Changes in airway diameter and mucus plugs in patients with asthma exacerbation.

PLoS ONE, 2020
BACKGROUND:Airway obstruction due to decreased airway diameter and increased incidence of mucus plugs has not been directly observed in asthma exacerbation. We studied the changes in the inner diameter of the airway (Din) and the frequency of mucus plugs
Yuki Yoshida, Yotaro Takaku, Yasuo Nakamoto, Noboru Takayanagi, Tsutomu Yanagisawa, Hajime Takizawa, Kazuyoshi Kurashima   +6 more
doaj   +1 more source

Small but Strong: Lightweight Architecture Improves Lung Nodule Detection and Segmentation

Advanced Intelligent Systems, EarlyView.
(a) Separated network architecture, where the lung nodule detection and segmentation networks are separated. (b) Separated head architecture, where an anchor‐based head is responsible for detection and another head for segmentation. (c) The study's architecture, containing a lightweight backbone network based on deformable Transformer for feature ...
Lilu Liu, Xiuping Nie, Haojian Lu, Jian Hu, Qi Dou, Rong Xiong, Yue Wang   +6 more
wiley   +1 more source

The Action of Chlorine, Etc., on the Bronchi: Report to the Chemical Warfare Committee [PDF]

, 1920
J. A. Gunn
openalex   +1 more source

AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics

Advanced Intelligent Systems, EarlyView.
This review outlines recent advances in integrating artificial intelligence with microphysiological systems for nanoparticle evaluation. It highlights data‐driven optimization, image‐based prediction, and AI‐enabled analysis frameworks that advance translational research and support the development of personalized nanomedicine. Nanoparticles (NPs) play
Yedam Lee, Jaehong Min, Sujin Kim, Jihoon Ko   +3 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Mounier-Kuhn Syndrome

Journal of the Belgian Society of Radiology, 2015
Background: A 38-year-old male with no medical history complains about hemoptysis, chest pain, dyspnea on exertion and a cough. He has a history of occasional smoking, but had quitted smoking 1 year previously.
E. Schiettecatte, E. Van Hedent, R. Van Herreweghe, K. Verstraete   +3 more
doaj   +1 more source

Occupational Asthma to UV‐Hardened Acrylate‐Based Car Paint

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Products containing acrylates are used in the coating of metal surfaces. Previous case series have reported occupational asthma caused by various acrylates including solitary cases related to coating products. We report on a case of occupational asthma caused by a new type of UV‐hardened car paint that included several reactive acrylates ...
Hille Suojalehto, Saara Eskola, Henna Kuparinen, Irmeli Lindström, Katri Suuronen   +4 more
wiley   +1 more source