Results 101 to 110 of about 533,230 (332)

Myeloid cAMP Reduction Shifts Rhinovirus‐Induced Airway Inflammation From Neutrophilic to Eosinophilic by Suppressing M1‐Interstitial Macrophages

open access: yesAllergy, EarlyView.
ABSTRACT Background Asthma exacerbations caused by human rhinovirus (hRV) infection are characterized by airway neutrophilia and reduced corticosteroid response, leading to significant healthcare costs and lung function impairment. The Gαs subunit of the trimeric G protein regulates immunopathological conditions by modulating cAMP levels.
Seong Ok Park   +9 more
wiley   +1 more source

Real‐Life Clinical Experience With SQ Grass, Tree, Ragweed, and House Dust Mite Sublingual Immunotherapy Tablets: A Review of Evidence From Non‐Interventional Studies

open access: yesAllergy, EarlyView.
ABSTRACT This review evaluates data from > 12,000 children, adolescents and adults (≥ 4 years) in non‐interventional studies to assess the real‐life effectiveness and safety of SQ sublingual immunotherapy (SLIT)‐tablets for allergic rhinitis (AR).
Oliver Pfaar   +4 more
wiley   +1 more source

Diversity and Dosage Determine the Efficacy of the Probiotic SYN‐53 in Allergic Rhinoconjunctivitis: A Randomized, Double‐Blind, Placebo‐Controlled Trial

open access: yesAllergy, EarlyView.
The probiotic food supplement SYN‐53 has previously shown efficacy in managing allergic rhinoconjunctivitis (ARC), with its high bacterial diversity and dosage hypothesized as key drivers. This study on 166 subjects aimed to confirm this hypothesis by comparing the effects of SYN‐53, a low dose variant (SYN‐53‐LD), a low diversity variant (SYN‐4), and ...
Karl‐Christian Bergmann   +1 more
wiley   +1 more source

Microenvironment‐Driven Mast Cell Plasticity: Insights From Cytokine‐Activated Gene Signatures in Skin and Respiratory Diseases

open access: yesAllergy, EarlyView.
Primary peripheral blood‐derived human mast cells exposed to IFNγ, IL‐33, IL‐4 + IL‐13, or TGFβ develop distinct transcriptional signatures with unique functional changes including degranulation and cytokine/chemokine release. Machine learning‐defined minimal cytokine‐activated signatures (245 genes) successfully detect cytokine‐primed mast cells in ...
Chiara Tontini   +5 more
wiley   +1 more source

Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

open access: yesAllergy, EarlyView.
This study aims to investigate how immune activation influences the epigenetic regulation and expression of the Interleukin‐6 (IL‐6) gene during asthma exacerbations. By examining molecular mechanisms of immune training, we seek to elucidate how IL‐6‐driven inflammatory pathways contribute to airway dysfunction and worsening asthma symptoms.
Lars P. Lunding   +34 more
wiley   +1 more source

SOME FUNCTIONAL FEATURES OF COURSE OF BRONCHIAL ASTHMA COMBINED WITH ESSENTIAL HYPERTENSION

open access: yesActa Biomedica Scientifica, 2015
One of the frequent conditions which accompany bronchial asthma is essential hypertension. The authors compared the functional characteristics of patients with isolated asthma and bronchial asthma combined with essential hypertension.
O. M. Uryasev, A. I. Rogachikov
doaj  

Pathology of Bronchial Asthma [PDF]

open access: green, 1883
NULL AUTHOR_ID
openalex   +1 more source

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