Results 31 to 40 of about 3,079,625 (227)

The sensitivity and specificity of the mannitol bronchial challenge test to identify asthma in different populations: a systematic review

Swiss Medical Weekly, 2019
OBJECTIVE Asthma is associated with bronchial hyperresponsiveness, assessed by bronchial provocation tests such as the mannitol test. We aimed to assess the data on sensitivity and specificity of the mannitol test in diagnosing asthma.
Philipp Kernen, Esther H. Steveling-Klein, Ramon T. Saccilotto, Heike Raatz, Matthias Briel, Michael T. Koller, Marie Westwood, Heiner C. Bucher, David Miedinger, Jörg D. Leuppi   +9 more
doaj   +1 more source

Effect of mannitol dry powder challenge on exhaled nitric oxide in children. [PDF]

PLoS ONE, 2013
BackgroundFractional exhaled nitric oxide (FENO), a non-invasive marker of eosinophilic airway inflammation, is increasingly used for diagnostic and therapeutic decisions in adult and paediatric asthma. Standardized guidelines for the measurement of FENO
Juerg Barben, Marie-Pierre F Strippoli, Daniel Trachsel, Barbara Schiller, Juerg Hammer, Claudia E Kuehni   +5 more
doaj   +1 more source

Work-related asthma

Jornal Brasileiro de Pneumologia, 2021
Work-related asthma (WRA) is highly prevalent in the adult population. WRA includes occupational asthma (OA), which is asthma caused by workplace exposures, and work-exacerbated asthma (WEA), also known as work-aggravated asthma, which is preexisting or ...
Lavinia Clara Del Roio, Rafael Futoshi Mizutani, Regina Carvalho Pinto, Mário Terra-Filho, Ubiratan Paula Santos   +4 more
doaj   +2 more sources

EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity.

, 2007
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type.
Nizankowska-Mogilnicka, E;Bochenek, G;Mastalerz, L;Swierczy?ska, M;Picado, C;Scadding, G;Kowalski, ML;Setkowicz, M;Ring, J;Brockow, K;Bachert, C;Wöhrl, S;Dahlén, B;Szczeklik, A
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

A SETUP TO CONDUCT BRONCHIAL PROVOCATION TESTING FOR CHILDREN UNDER 6 YEARS OLD

, 2022
A SETUP TO CONDUCT BRONCHIAL PROVOCATION TESTING FOR CHILDREN UNDER 6 YEARS ...
E Hor (13371687), S Devadason (13371696), W H Finlay (13371690), Peter Sly (13095165), S Leung (12146091), S D Anderson (13371699), P Tang (9097046), H-K Chan (13371702), J D Brannan (13371693)   +8 more
core  

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma

BMC Pulmonary Medicine, 2019
Background Bronchial provocation is often used to confirm asthma. Dyspnea sensation, however, associates poorly with the evoked drop in FEV1. Provocation tests only use the large airways parameter FEV1, although dyspnea is associated with both large- and
Claire A. Cox, Ilse M. Boudewijn, Sebastiaan J. Vroegop, Siebrig Schokker, Anne J. Lexmond, Henderik W. Frijlink, Paul Hagedoorn, Judith M. Vonk, Martijn P. Farenhorst, Nick H. T. ten Hacken, Huib A. M. Kerstjens, Maarten van den Berge   +11 more
doaj   +1 more source

Engineering an artificial trachea: Quantitative benchmarks and modular strategies for mechanics, epithelialization, and vascular integration

FlexMat, EarlyView.
In this work, we first examine the limitations of surgical repair and stenting, including migration, granulation, mucus plugging, and infection. We then translate these failures into engineering constraints involving geometry, mechanics, fixation, degradation, junctional stress, and remodeling.
Yiwei Xu, Hanqing Dai, Qianwang Ye, Wanlu Zhang, Na Wang, Lei Xiong, Ruiqian Guo   +6 more
wiley   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source