Results 71 to 80 of about 100,703 (254)

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Cytomegalovirus in Bronchoalveolar Lavage Fluid: A Predictor of Outcome in Immunocompromised Patients. [PDF]

J Med Virol
ABSTRACT Cytomegalovirus (CMV) is a prevalent herpesvirus that remains typically asymptomatic in immunocompetent individuals but can cause severe, potentially life‐threatening disease in immunocompromised patients. This study assessed the impact of CMV‐associated lower respiratory tract infections (LRTIs), diagnosed by polymerase chain reaction (PCR ...
Zouvani T, Karakioulaki M, Jahn K, Fähndrich S, Frye BC, Grize L, Papakonstantinou E, Hengel H, Leuzinger K, Hirsch HH, Stolz D.   +10 more
europepmc   +2 more sources

Comparative Diagnostic Performance of Three Commercial Real‐Time PCR Assays for the Detection of Mycobacterium tuberculosis Complex in Bronchial Washing Specimens: A Large Retrospective Study

Journal of Clinical Laboratory Analysis, EarlyView.
This large retrospective study compared the diagnostic performance of three commercial real‐time PCR assays (AdvanSure TB/NTM, Cobas MTB, and Xpert MTB/RIF) for MTBC detection in 3348 bronchial washing specimens. In a head‐to‐head comparison of 740 specimens, the Cobas MTB and Xpert MTB/RIF assays showed markedly higher sensitivity than the AdvanSure ...
Jimyung Kim, Yumi Park
wiley   +1 more source

Effects of washing procedures on cell loss in different diagnostic flow cytometry sample types

Cytometry Part B: Clinical Cytometry, EarlyView.
Gunnhild Vatne Leirvik, Trude Westgård, Mona Høysæter Fenstad, Henning Sørensen Øfsteng, Toril Holien   +4 more
wiley   +1 more source

Triggering Receptor Expressed on Myeloid Cells‐2 Regulates Innate Lymphoid Cell Levels in Bleomycin‐Induced Pulmonary Fibrosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Idiopathic pulmonary fibrosis, a pathological change causing poor outcomes, is not reversible despite current antifibrotic therapy. Emerging evidence suggests that innate lymphoid cells (ILCs) mediate lung inflammation and fibrosis after stimulation by endogenous factors.
Hsiao‐Chin Shen, Nien‐Jung Chen, Chuan‐Yen Sun, Wen‐Kuang Yu, Vincent Yi‐Fong Su, Wan‐Ling Yang, Wei‐Chih Chen, Kuang‐Yao Yang   +7 more
wiley   +1 more source

Andrographolide Modulates Fibrogenic and Oxidative Stress Responses in Human Lung Fibroblasts

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pulmonary fibrosis is a progressive lung disorder characterized by fibroblast activation and excessive extracellular matrix deposition. Andrographolide (ANDRO) has been reported to attenuate pulmonary fibrosis, but the underlying molecular mechanisms remain incompletely understood.
Yu‐Hsin Tseng, Yen‐Hsien Wu, Yi‐Ching Liu, I‐Chen Chen, Chung‐Yu Yeh, Shang‐En Huang, Ren‐Long Jan, Jwu‐Lai Yeh, Jong‐Hau Hsu   +8 more
wiley   +1 more source

Ginsenoside Rg1 Ameliorates LPS‐Induced Sepsis‐Associated Lung Injury in Mice via VEGFC/D‐VEGFR3 Signaling‐Mediated Lymphangiogenesis and Lymphatic Remodeling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced acute lung injury (ALI) remains challenging to treat, with conventional anti‐inflammatory therapies offering limited efficacy. The lymphatic system is crucial for removing edema and inflammatory mediators, and its impairment can exacerbate lung injury.
He Wang, Lan Hu, Chun‐Pan Zhang, Wen‐Jie Qi, Yu‐Guo Song   +4 more
wiley   +1 more source

Olaparib Blocks Oxidative Stress‐Dependent NLRP3 Inflammasome in Pediatric Acute Lung Injury by Metabolic Reprogramming via AMPK‐Driven Autophagic Flux

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric acute lung injury (ALI) is a life‐threatening syndrome defined by dysregulated pulmonary inflammation and impaired alveolar gas exchange, with limited therapeutic interventions. This study aims to evaluate the therapeutic efficacy and mechanistic basis of Olaparib, a clinically approved PARP inhibitor, using in vitro and in vivo ...
Fen Gong, Mei‐Ling Yu, Zheng‐Rong Chen, Mei Li, Xu Sang, Yong‐Dong Yan   +5 more
wiley   +1 more source

A case of legionellesis pneumonia verified by isolation of legionella pneumophila serogroup 1 from bronchoalveolar lavage treated with levofloxacine and tigecycline

Терапевтический архив, 2011
A male patient received non-chemotherapeutic drugs which induced deep neutropenia complicated with sepsis, bilateral pneumonia, acute respiratory insufficiency. Artificial pulmonary ventilation was applied.
Gennadiy Martinovich Galstyan, Mikhail Yur'evich Drokov, Svetlana Aleksandrovna Katrysh, Galina Aleksandrovna Klyasova, Elena Aleksandrovna Gilyazitdinova, Tat'yana Igorevna Karpova, Boris Ivanovich Marakusha, Igor' Semenovich Tartakovskiy, G M Galstyan, M Yu Drokov, S A Katrysh, G A Klyasova, E A Gilyazitdinova, T I Karpova, B I Marakusha, I S Tartakovsky   +15 more
doaj