Results 11 to 20 of about 201,059 (326)

Lipoxin A4 Regulates M2 Macrophage-Derived Exosomal miR-25-5p to Protect Cell Pyroptosis in Bronchopulmonary Dysplasia. [PDF]

FASEB J
In premature infants with BPD treated with LXA4, circulating monocytes are reprogrammed and polarized into M2‐Mφs and then migrate into the lungs. The M2‐exo released by M2‐Mφs, which is rich in miR‐25‐5p, downregulates the PI3K/AKT signaling pathway by acting on the target gene NRBP2, thereby inhibiting the pyroptosis of AT2.
Chen T, Yang Y, Zhang Y, You M, Zhou Y, Ning T, Lu H, Wang J, Peng S, Chen X.   +9 more
europepmc   +3 more sources

Bronchopulmonary Dysplasia: Pathogenesis and Pathophysiology

Journal of Clinical Medicine, 2023
Bronchopulmonary dysplasia (BPD), also known as chronic lung disease, is the most common respiratory morbidity in preterm infants. “Old” or “classic” BPD, as per the original description, is less common now.
Nilesh Dankhara, I. Holla, S. Ramarao, Renjithkumar Kalikkot Thekkeveedu   +3 more
semanticscholar   +1 more source

Tracheostomy in Severe Bronchopulmonary Dysplasia—How to Decide in the Absence of Evidence

Biomedicines, 2023
Infants with the most severe forms of bronchopulmonary dysplasia (BPD) may require long-term invasive positive pressure ventilation for survival, therefore necessitating tracheostomy.
Audrey N. Miller, Edward G. Shepherd, Amy Manning, Humra Shamim, Tendy Chiang, George El-Ferzli, Leif D. Nelin   +6 more
doaj   +1 more source

Diagnosis and management of bronchopulmonary dysplasia

British medical journal, 2021
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants and is associated with increased mortality, respiratory morbidity, neurodevelopmental impairment, and increased healthcare costs.
Margaret A Gilfillan, A. Bhandari, V. Bhandari   +2 more
semanticscholar   +1 more source

Severity of Bronchopulmonary Dysplasia Among Very Preterm Infants in the United States

Pediatrics, 2021
BrightcoveDefaultPlayer 10.1542/6250519228001 PEDS-VA_2020-030007 Video Abstract BACKGROUND AND OBJECTIVES The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network recently proposed new, severity-based
E. Jensen, Erika M. Edwards, Lucy T. Greenberg, R. Soll, D. Ehret, J. Horbar   +5 more
semanticscholar   +1 more source

Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia.

New England Journal of Medicine, 2022
BACKGROUND Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development.
Kristi L. Watterberg, Michele C. Walsh, Lei Li, S. Chawla, C. D’Angio, R. N. Goldberg, S. Hintz, Matthew M Laughon, B. A. Yoder, Kathleen A. Kennedy, G. McDavid, C. Backstrom-Lacy, Abhik Das, Margaret M. Crawford, Martin Keszler, G. M. Sokol, Brenda B. Poindexter, Namasivayam Ambalavanan, A. Hibbs, William E. Truog, Barbara Schmidt, M. Wyckoff, Amir M. Khan, M. Garg, P. R. Chess, A. M. Reynolds, Mohannad Moallem, Edward F. Bell, Lauritz R. Meyer, R. M. Patel, K. V. van Meurs, C. Cotten, E. C. McGowan, A. C. Hines, S. Merhar, M. Peralta-Carcelen, D. Wilson-Costello, H. Kilbride, S. Demauro, Roy J Heyne, R. A. Mosquera, Girija Natarajan, I. B. Purdy, J. R. Lowe, Nathalie L. Maitre, H. Harmon, L. A. Hogden, I. Adams-Chapman, S. Winter, W. F. Malcolm, R. Higgins   +50 more
semanticscholar   +1 more source

Stem-Cell Therapy for Bronchopulmonary Dysplasia (BPD) in Newborns

Cells, 2022
Premature newborns are at a higher risk for the development of respiratory distress syndrome (RDS), acute lung injury (ALI) associated with lung inflammation, disruption of alveolar structure, impaired alveolar growth, lung fibrosis, impaired lung ...
Said A Omar, A. Abdul-Hafez, S. Ibrahim, Natasha Pillai, Mohammed Abdulmageed, Ranga P. Thiruvenkataramani, Tarek Mohamed, B. Madhukar, B. Uhal   +8 more
semanticscholar   +1 more source

Area deprivation and respiratory morbidities in children with bronchopulmonary dysplasia

Pediatric Pulmonology, 2022
Infants and children diagnosed with bronchopulmonary dysplasia (BPD) have a higher likelihood of recurrent hospitalizations and asthma‐like symptoms. Socio‐environmental factors that influence the frequency and severity of pulmonary symptoms in these ...
Emma Banwell, J. Collaco, G. Oates, J. Rice, L. Juarez, L. Young, S. McGrath-Morrow   +6 more
semanticscholar   +1 more source

Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial [PDF]

, 2019
Background Infections acquired in hospital are an important cause of morbidity and mortality in very preterm infants. Several small trials have suggested that supplementing the enteral diet of very preterm infants with lactoferrin, an antimicrobial ...
Ainsworth, S, Bartle, D, Batra, D, Baum, A, Berrington, J, Bowler, U, Boyle, E, Bradburn, M, Clarke, P, Cooke, R, Craig, S, Dorling, J, ELFINTI Grp, Ellis, S, Embleton, N, Ewer, A, Garg, S, Geethanath, R, Gibson, D, Gowda, G, Griffiths, J, Gupta, R, Halliday, H, Heath, P, Hellier, J, Holder, G, Hutchison, F, Janakiraman, S, Jenkins, P, Johnson, K, Johnson, M, Juszczak, E, Kennea, N, King, A, Kumar, Y, Ledwidge, M, Linsell, L, Mactier, H, Manjunatha, CM, Mannix, P, Matthes, J, McGuire, W, Millar, M, Murray, D, Oddie, S, Ohadike, P, Partlett, C, Patel, M, Peters, C, Piling, E, Quine, D, Reynolds, P, Roehr, C, Scorrer, T, Story, I, Subhedar, N, Vailcutz, R, Vargova, M, Vasu, V, Yates, H   +59 more
core   +2 more sources

Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies

Disease Models & Mechanisms, 2021
Bronchopulmonary dysplasia (BPD) is a chronic lung disease caused by exposure to high levels of oxygen (hyperoxia) and is the most common complication that affects preterm newborns. At present, there is no cure for BPD.
Kiersten Giusto, Heather Wanczyk, Todd Jensen, C. Finck   +3 more
semanticscholar   +1 more source