Results 281 to 290 of about 449,656 (341)

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

open access: yesAdvanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang   +4 more
wiley   +1 more source

Cell Viability, Drug Screening, and Mechanism Study Under Mild Phototherapy Integrated Chemotherapy (PIC)

open access: yesAdvanced Science, EarlyView.
Mild phototherapy integrated chemotherapy (mild‐PIC) monitored by real‐time impedance spectroscopy enhances drug efficacy in liver cancer via the “More Light‐Aiding, Less Bonding (LALB)” mechanism, achieving higher targeting with lower toxicity. Abstract Phototherapy integrated chemotherapy (PIC) offers a promising cancer treatment strategy as single ...
Tongge Li   +15 more
wiley   +1 more source

Highly Ordered DNA Framework Interface Enables Efficient Enzymatic Oligonucleotide Synthesis

open access: yesAdvanced Science, EarlyView.
Tetrahedral DNA nanostructures (TDN) ‐based nanoscopic interface provides ordered upright orientation and optimal spacing for initiator primers, enhancing enzyme accessibility in interfacial enzymatic oligonucleotide synthesis (EOS). Notably, efficient TDN‐based EOS is employed for DNA information storage by synthesizing a 60‐nucletide DNA fragment ...
Kunjie Li   +9 more
wiley   +1 more source

Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1

open access: yesAdvanced Science, EarlyView.
TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji   +9 more
wiley   +1 more source

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