Results 131 to 140 of about 36,754 (262)

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

open access: yesBMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie   +12 more
wiley   +1 more source

Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

open access: yesBMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen   +10 more
wiley   +1 more source

Describing and Modeling Rough Composites Surfaces by Using Topological Data Analysis and Fractional Brownian Motion. [PDF]

open access: yesPolymers (Basel), 2023
Runacher A   +6 more
europepmc   +1 more source

Building phenotypic character matrices for phylogenetic inference: exploration of 35 years of practice

open access: yesBiological Reviews, EarlyView.
ABSTRACT Recent methodological development in phylogenetic inference has focused predominantly on molecular data. However, renewed interest in other data types, particularly morphological data, has followed from the increased recognition of the power of total evidence and tip‐dating approaches, including fossil data, for inference of time‐scaled trees ...
Melanie J. Hopkins   +9 more
wiley   +1 more source

The SIR Model in a Moving Population: Propagation of Infection and Herd Immunity

open access: yesCommunications on Pure and Applied Mathematics, EarlyView.
ABSTRACT In a collection of particles performing independent random walks on Zd$\mathbb {Z}^d$ we study the spread of an infection with SIR dynamics. Susceptible particles become infected when they meet an infected particle. Infected particles heal and are removed at rate ν$\nu$.
Duncan Dauvergne, Allan Sly
wiley   +1 more source

Synergistic mechanisms foster declines in native fish community stability following the introduction of non‐native species

open access: yesEcography, EarlyView.
Non‐native species introductions profoundly alter freshwater communities, yet the mechanisms by which non‐native fishes affect native community stability remain unclear. Using a multi‐decadal dataset on fish community composition and abundance collected across France, we quantified native community stability and decomposed this metric into its main ...
Chengzong Tian   +5 more
wiley   +1 more source

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