A BtpB‐Deleted Brucella Vaccine Strain Provides Dual Advantages: Enhanced Protection and Diagnostic Differentiation Capability in Mice [PDF]
Microbial BiotechnologyThe Brucella abortus A19 attenuated live vaccine poses potential infection risks during practical applications and interferes with serological diagnostics, thereby affecting quarantine measures and the establishment of disease‐free zones.
Zhenyu Xu +12 more
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Establishment of a dual droplet digital PCR method for detecting the Brucella abortus A19-ΔVirB12 strains [PDF]
Frontiers in MicrobiologyBrucellosis is a zoonosis that occurs worldwide, and vaccination is the main strategy for controlling it. In China, the Brucella abortus A19-ΔVirB12 strain is utilized in main vaccines.
Ruixue Xue +21 more
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The Role of Outer Membrane Protein 16 in Brucella Pathogenesis, Vaccine Development, and Diagnostic Applications [PDF]
Veterinary SciencesBrucellosis, caused by Brucella species, remains a significant zoonotic disease affecting both human and animal health worldwide. Among the outer membrane proteins (Omps) of Brucella, Omp16 has emerged as a key immunogenic target with potential ...
Lu Zhang +7 more
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Design of a multi-Epitope mRNA vaccine against Brucella type IV secretion system using reverse vaccinology and immunogenicity approaches [PDF]
Scientific ReportsBrucellosis is a zoonotic disease caused by bacteria of the Brucella genus. This study investigates the development of a multi-epitope mRNA vaccine aimed at combating Brucella infections. The approach involves selecting the architecture of the pathogenic
Jia-Rui Luo +9 more
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LDH as an adjuvant makes Brucella outer-membrane vesicles and outer-membrane vesicle-associated proteins highly protective in mice [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Existing Brucella vaccines are attenuated and can cause vaccine-associated brucellosis; and these safety concerns have affected their application.
Xiaoyu Deng +8 more
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One-step preparation of a self-assembled bioconjugate nanovaccine against Brucella
Virulence, 2023 Brucellosis, caused by Brucella, is a severe zoonosis, and the current Brucella live attenuated vaccine cannot be used in humans due to major safety risks.
Jing Huang +9 more
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Development of New Modified Simple Polymerase Chain Reaction and Real-time Polymerase Chain Reaction for the Identification of Iranian Brucella abortus Strains [PDF]
Archives of Razi Institute, 2019 Brucellosis is primarily a worldwide zoonotic disease caused by Brucella species. The genus Brucella contains highly infectious species that are classified as biological threat agents.
S. Alamian +4 more
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Journal of Immunology Research, 2022 Brucella is a globally distributed zoonotic disease that can cause abortion and changes in immune function in humans and animals. At present, there is no good treatment plan for Brucella, and animals can only be treated harmlessly once they become ill ...
Shuai Zhang +7 more
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Evaluation of Brucellosis Vaccines: A Comprehensive Review
Frontiers in Veterinary Science, 2022 Brucellosis is a bacterial zoonosis caused by Brucella spp. which can lead to heavy economic losses and severe human diseases. Thus, controlling brucellosis is very important.
Mohsen Heidary +7 more
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Progress in Brucella vaccine development [PDF]
Frontiers in Biology, 2012 Brucella spp. are zoonotic, facultative intracellular pathogens, which cause animal and human disease. Animal disease results in abortion of fetuses; in humans, it manifests flu-like symptoms with an undulant fever, with osteoarthritis as a common complication of infection.
Xinghong, Yang +5 more
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