Results 31 to 40 of about 7,748 (181)

The deletion of omp19 gene of brucella abortus 2308 reduces its survival in mouse macrophage and in mice [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020
The aim of this study is to investigate the role of outer membrane protein Omp19 of Brucella in its pathogenesis. In this research, the Brucella 2308 ΔOmp19 deletion mutant was constructed and its intracellular survivability was evaluated in murine ...
Yueli WANG, Zhongchen MA, Huan ZHANG, Jihai YI, Yong WANG, Tiansen LI, Chuangfu CHEN   +6 more
doaj   +1 more source

Bioinformatics analysis of Brucella vaccines and vaccine targets using VIOLIN [PDF]

Immunome Research, 2010
Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis, one of the commonest zoonotic diseases found worldwide in humans and a variety of animal species. While several animal vaccines are available, there is no effective and safe vaccine for prevention of brucellosis in humans.
He, Yongqun, Xiang, Zuoshuang
openaire   +3 more sources

Brucella melitensis Wzm/Wzt System: Changes in the Bacterial Envelope Lead to Improved Rev1Δwzm Vaccine Properties

Frontiers in Microbiology, 2022
The lipopolysaccharide (LPS) O-polysaccharide (O-PS) is the main virulence factor in Brucella. After synthesis in the cytoplasmic membrane, O-PS is exported to the periplasm by the Wzm/Wzt system, where it is assembled into a LPS. This translocation also
Sara Mena-Bueno, Sara Mena-Bueno, Irati Poveda-Urkixo, Oihane Irazoki, Leyre Palacios, Felipe Cava, Ana Zabalza-Baranguá, María Jesús Grilló   +7 more
doaj   +1 more source

Immunization of mice with recombinant protein CobB or AsnC confers protection against Brucella abortus infection. [PDF]

PLoS ONE, 2012
Due to drawbacks of live attenuated vaccines, much more attention has been focused on screening of Brucella protective antigens as subunit vaccine candidates.
Simei Fu, Jie Xu, Xianbo Li, Yongfei Xie, Yefeng Qiu, Xinying Du, Shuang Yu, Yaoxia Bai, Yanfen Chen, Tongkun Wang, Zhoujia Wang, Yaqing Yu, Guangneng Peng, Kehe Huang, Liuyu Huang, Yufei Wang, Zeliang Chen   +16 more
doaj   +1 more source

Genomic and Immunoinformatics Insights Into a Bovine-Derived Brucella abortus S19 Field Strain: Adaptations Impacting Vaccine Efficacy. [PDF]

Vet Med Sci
This study presents a comprehensive genomic and immunoinformatics analysis of a bovine‐derived Brucella abortus S19 field strain, revealing significant antigenic variations and virulence adaptations impacting vaccine efficacy. These findings provide insights for designing improved vaccines tailored to regional epidemiological needs.
Arslan A, Aktas E, Sezerman OU, Ozbek T.
europepmc   +2 more sources

A rapid minor groove binder PCR method for distinguishing the vaccine strain Brucella abortus 104M

BMC Veterinary Research, 2018
Background Brucellosis is a widespread zoonotic disease caused by Gram-negative Brucella bacteria. Immunisation with attenuated vaccine is an effective method of prevention, but it can interfere with diagnosis.
Wenlong Nan, Lide Qin, Yong Wang, Yueyong Zhang, Pengfei Tan, Yuqi Chen, Kairong Mao, Yiping Chen   +7 more
doaj   +1 more source

Bioinformatics-based design of a fusion vaccine with CTLA-4 variable region to combat Brucella

Brazilian Journal of Medical and Biological Research, 2023
Brucellosis has become a global zoonotic disease, seriously endangering the health of people all over the world. Vaccination is an effective strategy for protection against Brucella infection in livestock in developed countries. However, current vaccines
W.H. Guo, Y.J. Zhu, G. Haimiti, X.R. Xie, C. Niu, M. Li, J. Shi, Z.W. Yin, M.K. Yu, J.B. Ding, F.B. Zhang   +10 more
doaj   +1 more source

Vaccine safety studies of Brucella abortus S19 and S19ΔvjbR in pregnant swine

Vaccine: X, 2019
Brucellosis in swine is caused by Brucella suis, a bacterial infection of nearly worldwide distribution. Brucella suis is also transmissible to humans, dogs and cattle and is considered a reemerging disease of public health concern.
Slim Zriba, Daniel G. Garcia-Gonzalez, Omar H. Khalaf, Lance Wheeler, Sankar P. Chaki, Allison Rice-Ficht, Thomas A. Ficht, Angela M. Arenas-Gamboa   +7 more
doaj   +1 more source

Comparative genomic analysis between newly sequenced Brucella abortus vaccine strain A19 and another Brucella abortus vaccine S19

Genomics, 2020
Brucellosis is a bacterial disease caused by Brucella infection. Brucella abortus strain A19 is a spontaneously attenuated vaccine strain that has been used in vaccination of cattle against brucellosis. Until now, the physiological and molecular mechanisms of A19 are still unknown.In this paper, the whole-genome sequence of B. abortus A19 was performed
Shuyi, Wang, Wenlong, Wang, Ke, Sun, Huhe, Bateer, Xueliang, Zhao   +4 more
openaire   +2 more sources

Spatiotemporal Early Warning of Human Brucellosis in Hubei Province Using Coupled Ecological‐Time Series Models

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction This study explored transmission patterns of brucellosis in Hubei Province, a Class II region in China, through analysis of spatiotemporal distribution and environmental factors to provide evidence for precise prevention. Methods We analysed epidemiological data from Hubei Province (2010–2023), including human cases, demographics,
Qi Chen, Buasiyamu Abudunaibi, Xiaoying Zhao, Jiangshaya Bahati, Yao Wang, Jia Rui, Xuhua Guan, Tianmu Chen   +7 more
wiley   +1 more source