Results 51 to 60 of about 7,748 (181)

Attenuated Brucella melitensis Rough Rev1 Vaccine [PDF]

, 2004
The original objectives of the proposal were: 1. Compare mutants 444 and 710 to Rev1 (parent strain), and 16M (field strain) in murine and human macrophage lines for phenotypic differences. 2. Determine in vivo virulence and survival of the mutants 444 and 710 in guinea pigs and mice. 3.
Gary Splitter, Menachem Banai
openaire   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, Volume 13, Issue 10, 18 February 2026.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li, Lili Qiao, Xinquan Liang, Yingying Zhang, Ning Liang, Jian Xie, Guodong Deng, Yuying Hao, Pingping Hu, Xue Wu, Fangjie Ding, Can Feng, Yiming Mu, Jiandong Zhang   +13 more
wiley   +1 more source

Design of a multi-epitope vaccine candidate against Brucella melitensis

Scientific Reports, 2022
Brucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For Brucella, it is difficult to eliminate with current medical treatment.
Min Li, Yuejie Zhu, Ce Niu, Xinru Xie, Gulishati Haimiti, Wenhong Guo, Mingkai Yu, Zhiqiang Chen, Jianbing Ding, Fengbo Zhang   +9 more
doaj   +1 more source

Collaborative strategies for wildlife health: case studies from the Canadian North

The Journal of Wildlife Management, Volume 90, Issue 1, January 2026.
The integration of Indigenous perspectives with a One Health approach enables culturally relevant and sustainable zoonotic disease management and surveillance, as demonstrated through 4 case studies that highlight how empowering communities and facilitating inclusive, respectful, and collaborative governance across diverse sectors and knowledge systems
Cody J. Malone, Douglas A. Clark, N. Jane Harms, Naima Jutha, Geraldine‐G. Gouin, Malik Awan, Lisa‐Marie Leclerc, Gabriel Antwi‐Boasiako, Emily J. Jenkins   +8 more
wiley   +1 more source

An overview of Brucella vaccines

, 2022
Brucellosis is a worldwide zoonosis affecting both animal and human health. Till now, there is no effective vaccine licensed for brucellosis in humans. The current animal vaccines are S19, Rev.1, S2, RB51, and SR82, besides M5, H38, and 45/20 were once used to prevent animal brucellosis.
openaire   +1 more source

Survival and dispersal of brucella vaccine strain brucella abortus 19 in the body of vaccinated animals

Veterinaria i kormlenie, 2021
In the general complex of antibrucellosis measures, specific prevention of the disease occupies an important place. The first experiments on vaccination of animals against brucellosis were carried out in the early 20th century. Experiments have shown that even a single subcutaneous vaccination with a live virulent culture 2 months before fertilization ...
N.V. Vinokurov, E.S. Sleptsov, M.N. Sidorov, E.P. Tomashevskaia   +3 more
openaire   +1 more source

Field Evaluation of a Novel Combined Vaccine Against Porcine Circovirus Types 2a/d, Mycoplasma hyopneumoniae and Mycoplasma hyorhinis With an Emphasis on Growth Performance

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
A field trial on three commercial farms evaluated a combined vaccine targeting PCV2a/d, Mycoplasma hyopneumoniae, and Mycoplasma hyorhinis. Vaccinated pigs showed improved average daily weight gain, stronger immune responses against these pathogens, and significantly reduced viral and mycoplasmal loads and lesion severity, supporting its efficacy under
Jeongmin Suh, Sehyeong Ham, Hyejin Na, Ikjae Kang, Taehwan Oh, Youngkook You, Bumsoo Park, Chanhee Chae   +7 more
wiley   +1 more source

Thermostable Cross-Protective Subunit Vaccine against Brucella Species [PDF]

Clinical and Vaccine Immunology, 2014
ABSTRACTA subunit vaccine candidate was produced fromBrucella suis145 (biovar 4; expressing both the A antigen ofBrucella abortusand the M antigen ofBrucella melitensis). The preparation consisted mostly of polysaccharide (PS; >90% [wt/wt]; both cell-associated PS and exo-PS were combined) and a small amount of protein (1 to 3%) with no apparent ...
John W, Cherwonogrodzky, Nicole D, Barabé, Michelle L, Grigat, William E, Lee, Robert T, Poirier, Scott J, Jager, Bradley J, Berger   +6 more
openaire   +2 more sources

Advances in Microbial Diagnostics: Machine Learning and Nanotechnology for Zoonotic Disease Control

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 1, January/February 2026.
This review highlights how integrating machine learning with nanotechnology enables enhanced diagnostics, personalized treatments, and the prediction of outbreaks for zoonotic diseases, offering a unified framework to advance global health. ABSTRACT Zoonotic diseases pose significant global health threats, with microbial pathogens, including bacteria ...
Narges Lotfalizadeh, Cinzia Santucciu, Valentina Chisu, Helia Sepahvand, Abbas Rahdar, Razieh Behzadmehr, Octavio Luiz Franco, Guettari Moez, Luiz Fernando Romanholo Ferreira   +8 more
wiley   +1 more source