Results 61 to 70 of about 7,748 (181)

Contrasting roles for IgM and B-cell MHCII expression in Brucella abortus S19 vaccine-mediated efficacy against B. melitensis infection

open access: yesmSphere
Brucellosis, caused by the bacterium Brucella, poses a significant global threat to both animal and human health. Although commercial live Brucella vaccines including S19, RB51, and Rev1 are available for animals, their unsuitability for human use and ...
Mostafa F. N. Abushahba   +4 more
doaj   +1 more source

Towards Integrated Surveillance of Marine Brucellosis: Diagnostic and Phylogenetic Assessment of Brucella ceti in Stranded Dolphins of the Western Mediterranean Sea

open access: yesTransboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Reports of brucellosis in free‐ranging cetaceans are increasing worldwide, particularly in the Mediterranean Sea. To enhance diagnostic accuracy and epidemiological understanding of cetacean brucellosis in the Western Mediterranean Sea, we analyzed bacteriological, serological, and molecular data from 30 cetaceans belonging to three different species ...
Ignacio Vargas-Castro   +15 more
wiley   +1 more source

Brucella abortus Inhibits SIRT1 to Modulate Intracellular Survival and Autophagy in Macrophages

open access: yesTransboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Brucella spp., the causative agents of brucellosis, are facultative intracellular pathogens lacking classical virulence factors, and the disease represents one of the most prevalent zoonoses worldwide. Nevertheless, Brucella efficiently modulates the expression of genes associated with host cellular metabolism and immune evasion. The SIRT1 protein is a
Yuanhao Yang   +12 more
wiley   +1 more source

Establishment and application of a qPCR method for differential detection of Brucella S2 vaccine strain

open access: yesBMC Veterinary Research
Background Brucellosis is one of the most serious zoonotic bacterial diseases in the world. The disease has caused serious harm to people and livestock, hindered the healthy development of the breeding industry, and led to serious economic losses.At ...
Xianran Meng   +6 more
doaj   +1 more source

Investigation of the Seroprevalence of Brucella Antibodies and Characterization of Field Strains in Immunized Dairy Cows by B. abortus A19

open access: yesVeterinary Sciences
(1) Background: One method of eradicating brucellosis is to cull cattle that test positive for antibodies 12 months after being vaccinated with the 19-strain vaccine. Variations in immunization regimens and feeding practices may contribute to differences
Yong Shi   +16 more
doaj   +1 more source

Significant Impact of Schmallenberg Virus in Three Ruminant Farms: A Laboratory Experience

open access: yesVeterinary Medicine International, Volume 2026, Issue 1, 2026.
Schmallenberg virus (SBV) is endemic in Europe and other parts of the world and represents an underestimated and underdiagnosed cause of abortion and economic losses for livestock farms. In the present study, we evaluated SBV’s impact on three ruminant farms, in particular, two dairy cattle farms with reproductive problems (including abortions ...
Jacopo Guccione   +5 more
wiley   +1 more source

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

open access: yesDrug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu   +5 more
wiley   +1 more source

A novel IgG-Fc-Fused multiepitope vaccine against Brucella: robust immunogenicity

open access: yesMicrobial Cell Factories
Brucellosis is one of the most common zoonotic diseases caused by Brucella spp. However, there is currently no Brucella vaccine available for humans.
Aodi Wu   +17 more
doaj   +1 more source

The European Union One Health 2024 Zoonoses Report

open access: yesEFSA Journal, Volume 23, Issue 12, December 2025.
Abstract This report by the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring and surveillance activities carried out in 2024 in 27 Member States (MSs), the United Kingdom (Northern Ireland) and eight non‐MSs, according to the Zoonoses Directive 2003/99/EC.
European Food Safety Authority (EFSA) | European Centre for Disease Prevention and Control (ECDC)
wiley   +1 more source

Simultaneous Immunization with Omp25 and L7/L12 Provides Protection against Brucellosis in Mice

open access: yesPathogens, 2020
Currently used Brucella vaccines, Brucella abortus strain 19 and RB51, comprises of live attenuated Brucella strains and prevent infection in animals.
Sonal Gupta   +4 more
doaj   +1 more source

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