Results 171 to 180 of about 96,521 (257)

Receptor kinetics: Binding flux‐based approaches offer complementary insight into how ligand binding evolves with time

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Binding kinetics are essentially based on rate constants. Yet, this view has been challenged by the idea that ‘binding fluxes’ are dynamic and therefore more relevant. Those fluxes refer to the rate at which a target/receptor changes from one state into another through ligand/drug binding or a conformational change.
Georges Vauquelin   +2 more
wiley   +1 more source

Scientists’ warning on the global destruction of rock outcrop ecosystems

open access: yesConservation Biology, EarlyView.
Abstract Rock outcrops are geological formations that harbor a highly specialized biota adapted to harsh environmental conditions that differ from their surrounding landscapes. They are globally distributed, especially in old, highly weathered landscapes, and can function as habitat islands containing high levels of endemism and distinct evolutionary ...
Luiza F. A. de Paula   +19 more
wiley   +1 more source

Institutional Investor Impact Across Asset Classes: Exit, Voice, and/or Denial of Unconditional (Re)financing

open access: yesCorporate Governance: An International Review, EarlyView.
ABSTRACT Research Question/Issue The Voice versus Exit debate among institutional investors dissatisfied with corporate issuers remains narrowly framed: Academic inquiry is de facto limited to listed equities. This overlooks the role of governance in corporate financing, which due to refinancing cycles, represents a key lever for investors aiming to ...
Andreas G. F. Hoepner   +1 more
wiley   +1 more source

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