Results 61 to 70 of about 153,573 (294)

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Policing in Kenya during Covid-19

Kabarak Law Review, 2022
Kenya’s policing history has for the longest time been partisan to the ruling regime. This has created a culture of brutality and disdain among members of the Kenya Police, towards members of the public whom they ought to protect and serve. Although the
George Omondi Gor
doaj   +1 more source

Sports and the Politics of Identity and Memory: The Case of Federal Indian Boarding Schools During the 1930s [PDF]

, 1998
The federal government of the United States developed a complex System of boarding schools for Native Americans in the 19(th) century. This effort was generally insensitive and often brutal.
Bloom, John
core   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Tortured Logic: Information and brutality in interrogations (with debate)

Torture, 2018
Background: Pragmatic arguments for interrogational torture rest on the twin assumptions that torture generates reliable information and that torture can be controlled and limited. Click on pdf for full abstract.
John W. Schiemann
doaj   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Color/Identity/Justice: Chicano Trials [PDF]

, 2004
This Book Review seeks to rectify in small measure the omission of color from American documents of black/white legal and political struggle. Enlarging the spectrum of struggle beyond the black/white paradigm not only works to correct the historical ...
Alfieri, Anthony V.
core   +1 more source

Researching the use of force: The background to the international project [PDF]

, 2009
This article provides the background to an international project on use of force by the police that was carried out in eight countries. Force is often considered to be the defining characteristic of policing and much research has been conducted on the ...
A. Reiss, A. Reiss, A. Schuck, Amnesty International., B. Smith, C. A. J. Coady, C. Birkbeck, C. Birkbeck, C. Klockars, C. Klockars, C. Klockars, CELS (Centro de Estudios Legales y Sociales)., Christopher Birkbeck, D. Chappell, D. Stewart, D. Weisburd, David Baker, E. Bittner, E. Bittner, Eduardo Paes Machado, F. Jobard, G. Alpert, G. Alpert, G. Alpert, H. - J. Lange, H. Rahtz, I. Cano, I. Loader, J. Fyfe, J. Garner, J. Jäger, J. Jäger, J. Jäger, J. Jäger, J. Kleinig, J. MacDonald, J. Mars, J. McElvain, J. Ross, J. Timmer, J. Timmer, J. Wilson, J.-P. Brodeur, K. Adams, K. Amendola, K. Sessar, L. Gabaldón, L. Rossiter, Luis Gerardo Gabaldón, M. Hickman, M. Huggins, M. Huggins, M. Mopas, M. Norris, M. Straus, Maki Haberfeld, N. Kop, N. Uildriks, N. Uildriks, O. Adang, O. Adang, O. Adang, Otto Adang, P. A. J. Waddington, P. Bourdieu, P. Hoffman, P. Manzoni, P. Neyroud, P. Shuldiner, P. Stenning, P. Waddington, Philip Stenning, R. Briceño León, R. Del Olmo, R. E. Dobash, R. Ericson, R. Lawrence, T. Ohlemacher, T. Santos, Thomas Feltes, Urban Alliance on Race Relations/Queen Street Patients Council., W. Geller, W. Terrill, W. Terrill, W. Westley, Y. Monsalve   +85 more
core   +4 more sources

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Black Lives Matter: Decrypting Encrypted Racism [PDF]

, 2017
The agitation of the Black Lives Matter movement has dominated the public discourse in the United States. Mobilized against the killing of unarmed black people, the movement and their sympathizers have made a series of demands for justice and dignity for
Ugorji, Basil
core   +1 more source