Results 41 to 50 of about 5,286 (232)

Targeting Bruton's tyrosine kinase in B cell malignancies

, 2014
Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and functions as an important regulator of cell proliferation and cell survival in various B cell malignancies.
Hendriks, Rudi, Kil, Laurens, Laurens P. Kil, Rudi W. Hendriks, Saravanan Yuvaraj, Pillai, Saravanan   +5 more
core   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source

Ibrutinib, a Bruton's tyrosine kinase inhibitor, a new risk factor for cryptococcosis

, 2020
International audiencePurposeInvasive fungal diseases and especially Cryptococcus neoformans infections are increasingly reported in patients with hematological malignancies receiving ibrutinib, a Bruton's tyrosine kinase inhibitor.Patients and methodWe ...
Le Pape, Patrice, Mahe, B., Guimard, T., Mahe, Julien, Morio, F., Morrier, M., Brochard, Julia, Boutoille, D., Brochard, J., Raffi, F., Le Pape, P., Morio, Florent, Boutoille, David, Leterrier, M., Raffi, François, Mahe, J., Mahe, Béatrice   +16 more
core   +1 more source

Bruton's Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae

, 2022
Humans with dysfunctional Bruton's tyrosine kinase (Btk) are highly susceptible to bacterial infections. Compelling evidence indicates that Btk is essential for B cell-mediated immunity, whereas its role in myeloid cell-mediated immunity against ...
de Vos, Alex F., Liu, Zhe, de Porto, Alexander P. N. A., de Beer, Regina, Roelofs, Joris J. T. H., van der Poll, Tom, de Boer, Onno J., Florquin, Sandrine, van't Veer, Cornelis, Hendriks, Rudi W.   +9 more
core   +1 more source

Mutations of Bruton's tyrosine kinase gene in Brazilian patients with X-linked agammaglobulinemia [PDF]

, 2010
Mutations in Bruton's tyrosine kinase (BTK) gene are responsible for X-linked agammaglobulinemia (XLA), which is characterized by recurrent bacterial infections, profound hypogammaglobulinemia, and decreased numbers of mature B cells in peripheral blood.
RAMALHO, V.D., TANI, S.M., S.M. Tani, OLIVEIRA JÚNIOR, E.B., ROXO JÚNIOR, P., P. Roxo Júnior, VILELA, M.M.S., E.B. Oliveira Júnior, M.M.S. Vilela, V.D. Ramalho   +9 more
core   +3 more sources

The Different Faces of Chronic Lymphocytic Leukemia -Two Clinical Cases [PDF]

Journal of Biomedical & Clinical Research, 2020
Chronic lymphocytic leukemia is one of the most common types of leukemia affecting adults over 65 years of age [1]. The disease is a part of the so-called indolent lymphomas and has a variable clinical course, defined by many factors.
Vanya Popova, Kalina Ignatova, Dobromir Nguen, Pencho Tonchev, Doroteya Todorieva, Lachezar Bogdanov   +5 more
doaj   +3 more sources

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Prevention of the anti-factor VIII memory B-cell response by inhibition of the Bruton's tyrosine kinase in experimental hemophilia A

, 2019
International audienceHemophilia A is a rare hemorrhagic disorder due to the lack of functional pro-coagulant factor VIII. Factor VIII replacement therapy in patients with severe hemophilia A results in the development of inhibitory anti-factor VIII IgG ...
Ing, Mathieu, Srinivas V. Kaveri, Delignat, Sandrine, Bagirath Gangadharan, Jules Russick, Kaveri, Srinivas, Gangadharan, Bagirath, Sébastien Lacroix-Desmazes, Jan Voorberg, Sandrine Delignat, Russick, Jules, Mathieu Ing, Rayes, Julie, Kaveri, Srinivas V., Lacroix-Desmazes, S. bastien, Voorberg, Jan, Lacroix-Desmazes, Sébastien, Julie Rayes   +17 more
core   +1 more source

Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment [PDF]

, 2018
Tumour necrosis factor (TNF) is produced by primary human macrophages in response to stimulation by exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs) via Toll-like receptor (TLR ...
Page, Theresa H, Theresa H. Page, Smallie, Timothy, Lynn M. Williams, Horwood, Nicole J, Williams, Lynn M, Ana I. Espirito Santo, Williams, Lynn M., Urbaniak, Anna M, Danks, Lynett, Urbaniak, AM, Anna M. Urbaniak, Espirito Santo, Ana I, Page, Theresa H., Espirito Santo, Ana I., Page, TH, Urbaniak, Anna M., Horwood, Nicole, Timothy Smallie, Smallie, T, Lynett Danks, Nicole J. Horwood, Horwood, Nicole J.   +22 more
core   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source