Results 61 to 70 of about 204,412 (324)
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Bubbles, Bubbles Everywhere! [PDF]
Practical Neurology, 2003 Back in 1993 it had been a fairly average afternoon in the neurovascular clinic; a couple of obese, hypertensive smokers with clear-cut transient ischaemic attacks whose seemingly programmed lack of motivation to modify their vascular risk factors would subsequently challenge all the persuasive skills of my Specialist Nurse.
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Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Journal of High Energy Physics, 2019 AbstractWe build the first family of smooth bubbling microstate geometries that are asymptotic to the near-horizon region of extremal five-dimensional Kerr black holes (NHEK). These black holes arise as extremal non-supersymmetric highly-rotating D1-D5- P solutions in type IIB string theory on T4×S1.
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The Review of Economic Studies, 2011 This paper analyzes the possibility and the consequences of rational bubbles in a dynamic economy where financially constrained firms demand and supply liquidity. Bubbles are more likely to emerge, the scarcer the supply of outside liquidity and the more limited the pledgeability of corporate income; they crowd investment in (out) when liquidity is ...
Farhi, Emmanuel, Tirole, Jean
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei +6 more
wiley +1 more source
International Journal of Nanomedicine, 2019 Changsong Xu1,2,*, Feng Gao3,*, Jianrong Wu4, Shiwei Niu4, Fan Li3, Lifang Jin3, Qiusheng Shi3, Lianfang Du1,3 1Department of Ultrasound, Shanghai General Hospital of Nanjing Medical University, Shanghai 201600, People’s Republic of China ...
Xu C +7 more
doaj
Journal of High Energy Physics, 2012 We propose an alternative mechanism of baryogenesis in which a scalar baryon undergoes a percolating first-order phase transition in the early Universe. The potential barrier that divides the phases contains explicit B and CP violation and the corresponding instanton that mediates decay is therefore asymmetric.
Cheung, Clifford +2 more
openaire +4 more sources