Results 91 to 100 of about 2,139,463 (337)

Development and Characterization of Mucoadhesive Film of Nitrendipine for Buccal Administration

International Journal of Nano Studies & Technology, 2013
Mucoadhesive buccal patches containing nitrendipine were prepared using the solvent casting method. Chitosan was used as bio-adhesive polymer and different ratios of chitosan to PVP K-30 were used. The pre-formulation study using DSC revealed the compatibility of drug and polymer.
Chauhan N, Mittal A, U.K.Bajaj
openaire   +1 more source

CGRP‐Loaded ROS‐Responsive Hydrogel Restores Neuro‐Angiogenic Signaling to Promote Bone Regeneration in Diabetes‐Associated Periodontitis

Advanced Science, EarlyView.
This study shows that diabetes damages sensory nerve fibers, especially CGRP‐positive ones, in the periodontium and disrupts autophagy in trigeminal ganglion neurons, affecting bone homeostasis by inhibiting type H vessel formation. To address this, CGRP@PVA/tsPBA hydrogels are developed to release CGRP in response to ROS, which binds to endothelial ...
Chaoning Zhan, Qingyi Dai, Jianhan Ren, Lijian Jin, Weiping Wang, Zhou Ye, James Kit Hon Tsoi, Yifan Lin   +7 more
wiley   +1 more source

How Intuitive Is the Administration of Pediatric Emergency Medication Devices for Parents? Objective Observation and Subjective Self-Assessment

Pharmacy
Background: to assess the intuitiveness of parents’ administration of pediatric emergency devices (inhalation, rectal, buccal, nasal, and auto-injector).
Ruth Melinda Müller, Birthe Herziger, Sarah Jeschke, Martina Patrizia Neininger, Thilo Bertsche, Astrid Bertsche   +5 more
doaj   +1 more source

Preparation and Characterization of a Novel Mucoadhesive Carvedilol Nanosponge: A Promising Platform for Buccal Anti-Hypertensive Delivery

Gels, 2022
Carvedilol (CRV) is a non-selective third generation beta-blocker used to treat hypertension, congestive heart failure and angina pectoris. Oral administration of CRV showed poor bioavailability (25%), which might be ascribed to its extensive first-pass ...
El-Sayed Khafagy, Amr S. Abu Lila, Nahed Mohamed Sallam, Rania Abdel-Basset Sanad, Mahgoub Mohamed Ahmed, Mamdouh Mostafa Ghorab, Hadil Faris Alotaibi, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Ahmed Al Saqr, Shadeed Gad   +13 more
doaj   +1 more source

Use of buccal morphine in the management of pain in children with life-limiting conditions: Results of a laboratory study [PDF]

, 2018
BACKGROUND: Children and infants with impaired swallow or compromised enteral absorption require alternative routes for administration of analgesia. Recent clinical guidance and practice for paediatric palliative care teams, who often treat such children,
Bluebond-Langner, M, Henderson, EM, Lane, ME, McCulloch, R, Sattar, M   +4 more
core  

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Analytical profiling, modeling and transdermal/transmucosal characteristics of bioactive N-alkylamides [PDF]

, 2009
N-alkylamides are a group of bioactive molecules found in several plants. Extracts and formulations derived from these plants are not only used orally, but are applied on the skin and buccal mucosa as well.
Baert, Bram, Blondeel, Phillip, Boonen, Jente, Burvenich, Christian, De Spiegeleer, Bart   +4 more
core   +1 more source

Dual‐Pedicle Tissue‐Engineered Trachea Promotes Biomimetic Cartilaginous Framework, Vascularization, and Epithelial Lining for Long‐Segment Tracheal Reconstruction

Advanced Science, EarlyView.
Overcoming the limitations of conventional grafts, a biomimetic trachea with two independent vascular pedicles enables rapid integration and sustained patency. This approach markedly improves survival rates, restores the epithelial barrier, and promotes regenerative pathways, presenting a transformative paradigm for clinical application.
Ziming Wang, Yuming Wang, Zihao Chen, Erji Gao, Liang Guo, Juanjuan Li, Siqiang Zheng, Jiaoyu Yi, Zhe‐Sheng Chen, Bo Tao   +9 more
wiley   +1 more source

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Pharmaceuticals, 2020
Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing.
Georgios Eleftheriadis, Paraskevi Kyriaki Monou, Eleftherios Andriotis, Elisavet Mitsouli, Nikoleta Moutafidou, Catherine Markopoulou, Nikolaos Bouropoulos, Dimitrios Fatouros   +7 more
doaj   +1 more source

Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

Frontiers in Pharmacology, 2023
Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in patients with affective and other ...
Dario A. Dornbierer, Dario A. Dornbierer, Dario A. Dornbierer, Laurenz Marten, Laurenz Marten, Jovin Mueller, Helena D. Aicher, Helena D. Aicher, Helena D. Aicher, Michael J. Mueller, Michael J. Mueller, Michael J. Mueller, Martina Boxler, Michael Kometer, Davor Kosanic, Robin von Rotz, Maxim Puchkov, Thomas Kraemer, Hans-Peter Landolt, Hans-Peter Landolt, Erich Seifritz, Erich Seifritz, Milan Scheidegger, Milan Scheidegger   +23 more
doaj   +1 more source