Results 11 to 20 of about 27,341 (167)

Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration. [PDF]

Polymers (Basel), 2017
Furosemide loaded electrospun fibers were prepared for buccal administration, with the aim of improving the oral bioavailability of the poorly soluble and permeable crystalline drug, which can be achieved by the increased solubility and by the circumvention of the intensive first pass metabolism.
Kovács A, Démuth B, Meskó A, Zelkó R.   +3 more
europepmc   +7 more sources

Midazolam pharmacokinetics following intravenous and buccal administration [PDF]

British Journal of Clinical Pharmacology, 1998
Aims  Midazolam has good anxiolytic qualities and is a well established premedication agent before anaesthesia or short surgical procedures. The objective of the present study was to determine pharmacokinetic data from individual plasma concentration profiles obtained following intravenous and buccal administration of midazolam.
Rolf Schwagmeier, S. Alincic, H. W. Striebel   +2 more
openalex   +4 more sources

Mucoadhesive Tablets for Buccal Administration Containing Sodium Nimesulide [PDF]

Drug Delivery, 2004
The possibility of improving the flux of nimesulide across the buccal mucosa using the drug in the form of a sodium salt was investigated in our study. The salt form may increase to flux across buccal membrane, starting from a suspension; its lower permeation coefficient is compensated by a higher concentration gradient.
P. Maffei, S. Lombardi Borgia, A. Sforzini, Valentina Bergamante, G. C. Ceschel, A. Fini, C. Ronchi   +6 more
openalex   +6 more sources

MUCOADHESIVE POLYMERIC FILMS OF ACYCLOVIR PRONIOSOMES FOR BUCCAL ADMINISTRATION

International Journal of Applied Pharmaceutics, 2021
Objective: The aim of the present work was to formulate and evaluate proniosomes of the poorly soluble drug, acyclovir incorporated in mucoadhesive polymeric films for improved buccal mucosal permeability of the drug while achieving prolonged release. Methods: Acyclovir was formulated as proniosomes using Span 60 and cholesterol.
DEEKSHA U. SUVARNA, Marina Koland, Ananth Prabhu, S. M. Sindhoor   +3 more
openalex   +3 more sources

Incorrect administration of buccal glyceryl trinitrate [PDF]

Heart, 2002
A 66 year old man with documented coronary artery disease was brought by ambulance to the emergency department with severe anginal chest pain and pulmonary oedema. Two 2 mg buccal glyceryl trinitrate …
A. H. D. Watson, Lisa A. Michaels
openalex   +3 more sources

Pharmacokinetics of testosterone after percutaneous gel or buccal administration [PDF]

Fertility and Sterility, 2001
To determine the pharmacokinetics of testosterone following its administration using transdermal gel or buccal lozenges.Pilot study.University-based hospital.Ten bilaterally oophorectomized women.Daily micronized testosterone gel (1 mg) and testosterone propionate lozenge (1 mg).Total testosterone, androstenedione, dihydrotestosterone, 3alpha ...
Cristin C. Slater, Irene Souter, Chunying Zhang, Cha‐Xiang Guan, Frank Z. Stanczyk, Daniel R. Mishell   +5 more
openalex   +4 more sources

Assessing efficacy and safety of buccally inoculated midazolam and intravenously administered diazepam for relieving pediatric primary generalized epileptic seizures

Эпилепсия и пароксизмальные состояния, 2021
Objective: to confirm a therapeutic equivalence and similar safety profile of “Midazolam, oromucosal (buccal) solution” and “Sibazon, solution for intravenous and intramuscular administration” used in children aged from 1 year to 18 years suffering from ...
A. G. Prityko, K. V. Osipova, P. L. Sokolov, E. A. Ezhova, I. G. Kotel’nikova, E. G. Lukyanova, G. A. Osipova   +6 more
doaj   +1 more source

Significant hypotension following buccal midazolam administration [PDF]

BMJ Case Reports, 2010
Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus. It is available in various forms, including a buccal preparation with a strength of 10 mg/1 ml. Midazolam is a licensed medication, but the buccal formulation is currently used off-licence.
M. Kensche, Josemir W. Sander, Sanjay M. Sisodiya   +2 more
openalex   +4 more sources

New Technological Approaches for Dental Caries Treatment: From Liquid Crystalline Systems to Nanocarriers

Pharmaceutics, 2023
Dental caries is the most common oral disease, with high prevalence rates in adolescents and low-income and lower-middle-income countries. This disease originates from acid production by bacteria, leading to demineralization of the dental enamel and the ...
Marcela Tavares Luiz, Leonardo Delello di Filippo, Jessyca Aparecida Paes Dutra, Juliana Santos Rosa Viegas, Amanda Letícia Polli Silvestre, Caroline Anselmi, Jonatas Lobato Duarte, Giovana Maria Fioramonti Calixto, Marlus Chorilli   +8 more
doaj   +1 more source

PHARMACOKINETICS OF MORPHINE FOLLOWING ADMINISTRATION BY THE BUCCAL ROUTE

British Journal of Anaesthesia, 1989
The pharmacokinetics of morphine administered via the buccal route as a controlled release formulation were assessed after the administration of three different doses and found to be linear in the dose range 10-30 mg. The plasma concentrations of morphine-3-glucuronide and morphine-6-glucuronide demonstrated considerable inter-subject variation and ...
Alexander R. Manara, M. P. Shelly, K.G. QUINN, G.R. Park   +3 more
openalex   +4 more sources