Results 21 to 30 of about 2,104,096 (377)

Midazolam pharmacokinetics following intravenous and buccal administration [PDF]

British Journal of Clinical Pharmacology, 1998
Aims  Midazolam has good anxiolytic qualities and is a well established premedication agent before anaesthesia or short surgical procedures. The objective of the present study was to determine pharmacokinetic data from individual plasma concentration profiles obtained following intravenous and buccal administration of midazolam.
Rolf Schwagmeier, S. Alincic, H. W. Striebel   +2 more
openalex   +4 more sources

Mucoadhesive Tablets for Buccal Administration Containing Sodium Nimesulide [PDF]

Drug Delivery, 2004
The possibility of improving the flux of nimesulide across the buccal mucosa using the drug in the form of a sodium salt was investigated in our study. The salt form may increase to flux across buccal membrane, starting from a suspension; its lower permeation coefficient is compensated by a higher concentration gradient.
P. Maffei, S. Lombardi Borgia, A. Sforzini, Valentina Bergamante, G. C. Ceschel, A. Fini, C. Ronchi   +6 more
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Incorrect administration of buccal glyceryl trinitrate [PDF]

Heart, 2002
A 66 year old man with documented coronary artery disease was brought by ambulance to the emergency department with severe anginal chest pain and pulmonary oedema. Two 2 mg buccal glyceryl trinitrate …
A. H. D. Watson, Lisa A. Michaels
openalex   +3 more sources

Microemulsion containing triamcinolone acetonide for buccal administration

European Journal of Pharmaceutical Sciences, 2018
The aim of the present work was to investigate the potential of microemulsions for the buccal administration of triamcinolone acetonide. Microemulsions were developed by the construction of pseudoternary phase diagrams, using the aqueous titration method.
C. Padula, I. Telò, A. Di Ianni, S. Pescina, S. Nicoli, P. Santi   +5 more
semanticscholar   +5 more sources

MUCOADHESIVE POLYMERIC FILMS OF ACYCLOVIR PRONIOSOMES FOR BUCCAL ADMINISTRATION

International Journal of Applied Pharmaceutics, 2021
Objective: The aim of the present work was to formulate and evaluate proniosomes of the poorly soluble drug, acyclovir incorporated in mucoadhesive polymeric films for improved buccal mucosal permeability of the drug while achieving prolonged release. Methods: Acyclovir was formulated as proniosomes using Span 60 and cholesterol.
DEEKSHA U. SUVARNA, Marina Koland, Ananth Prabhu, S. M. Sindhoor   +3 more
openalex   +3 more sources

Pharmacokinetics of testosterone after percutaneous gel or buccal administration [PDF]

Fertility and Sterility, 2001
To determine the pharmacokinetics of testosterone following its administration using transdermal gel or buccal lozenges.Pilot study.University-based hospital.Ten bilaterally oophorectomized women.Daily micronized testosterone gel (1 mg) and testosterone propionate lozenge (1 mg).Total testosterone, androstenedione, dihydrotestosterone, 3alpha ...
Cristin C. Slater, Irene Souter, Chunying Zhang, Cha‐Xiang Guan, Frank Z. Stanczyk, Daniel R. Mishell   +5 more
openalex   +4 more sources

A comparison of buccal versus vaginal misoprostol administration for induction of first and second trimester abortion [PDF]

, 2023
Background: Aim of study was to compare effectiveness, adverse effects and patient’s acceptability of buccal and vaginal routes of administration of misoprostol in 1st and 2nd trimester abortion, type of study-randomized control trial Methods: A total of
Amita Yadav, Nikita Kaushal, Shubhangi Sonkar   +2 more
openalex   +3 more sources

Significant hypotension following buccal midazolam administration [PDF]

Case Reports, 2010
Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus. It is available in various forms, including a buccal preparation with a strength of 10 mg/1 ml. Midazolam is a licensed medication, but the buccal formulation is currently used off-licence.
M. Kensche, Josemir W. Sander, Sanjay M. Sisodiya   +2 more
openalex   +4 more sources

PHARMACOKINETICS OF MORPHINE FOLLOWING ADMINISTRATION BY THE BUCCAL ROUTE

British Journal of Anaesthesia, 1989
The pharmacokinetics of morphine administered via the buccal route as a controlled release formulation were assessed after the administration of three different doses and found to be linear in the dose range 10-30 mg. The plasma concentrations of morphine-3-glucuronide and morphine-6-glucuronide demonstrated considerable inter-subject variation and ...
Alexander R. Manara, M. P. Shelly, K.G. QUINN, G.R. Park   +3 more
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Serum morphine concentrations after buccal and intramuscular morphine administration. [PDF]

British Journal of Clinical Pharmacology, 1987
1. This study compared serum concentrations of morphine after administration of a buccal tablet (25mg) with those after intramuscular injection (10mg). 2. Buccal morphine was administered to eleven healthy volunteers and intramuscular morphine was given to five preoperative surgical patients.
A. P. Fisher, C. FUNG, Michael G. Hanna
openalex   +5 more sources