Results 21 to 30 of about 53,364 (321)
Pharmaceutics, 2021 Buccal drug delivery is a suitable alternative to invasive routes of drug administration. The buccal administration of insulin for the management of diabetes has received substantial attention worldwide.
Santosh Bashyal +5 more
doaj +1 more source
Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term
Clinical and Translational Science, 2022 The IMPROVE study (NCT02408315) compared the efficacy and safety of vaginal and buccal administration of misoprostol for full‐term, uncomplicated labor induction. This report compares the pharmacokinetics of misoprostol between vaginal and buccal routes.
Yana Vorontsova +10 more
doaj +1 more source
Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388. [PDF]
, 2020 COR388, a small-molecule lysine-gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease.
Arastu-Kapur, Shirin +10 more
core +1 more source
Absolute Bioavailability of Microdosed Midazolam After Buccal Administration Is Dependent on Buccal Exposure Time [PDF]
The Journal of Clinical Pharmacology, 2020 AbstractMidazolam is an established probe drug to assess cytochrome P450 3A activity (phenotyping). Microdosed midazolam is increasingly used for this purpose; a buccal formulation might be of advantage, but buccal absorption might occur. We therefore tested in a single‐center, open‐label clinical trial with 12 healthy volunteers the absolute ...
Jana Grass +5 more
openaire +2 more sources
Midazolam pharmacokinetics following intravenous and buccal administration [PDF]
British Journal of Clinical Pharmacology, 1998 Aims Midazolam has good anxiolytic qualities and is a well established premedication agent before anaesthesia or short surgical procedures. The objective of the present study was to determine pharmacokinetic data from individual plasma concentration profiles obtained following intravenous and buccal administration of midazolam.
R, Schwagmeier +2 more
openaire +2 more sources
Nano Biomedicine and Engineering, 2021 The present study was conducted to evaluate the impact of calcium oxide-nanoparticles (CaO-NPs) administration at different concentrations on the epithelial thickness, papilla length and number of blood vessels of male Wister rats' buccal mucosa, and the
Bushra Habeeb Al-Maula +5 more
doaj +1 more source
Incorrect administration of buccal glyceryl trinitrate [PDF]
Heart, 2002 A 66 year old man with documented coronary artery disease was brought by ambulance to the emergency department with severe anginal chest pain and pulmonary oedema. Two 2 mg buccal glyceryl trinitrate …
A Watson, L Michaels
openaire +1 more source
Pharmaceutics, 2021 The buccal mucosa provides an alternative route of drug delivery that can be more beneficial compared to other administration routes. Although numerous studies and reviews have been published on buccal drug delivery, an extensive review of the ...
Apipa Wanasathop +3 more
doaj +1 more source
An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems
Pharmaceutics, 2021 Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery, anatomical and physiological aspects of oral mucosa, and various in ...
Shery Jacob +5 more
doaj +1 more source
Survey of Provider Preferences Regarding the Route of Misoprostol for Induction of Labor at Term
American Journal of Perinatology Reports, 2017 Objective To survey obstetrical provider preferences regarding use of misoprostol for induction of labor (IOL). Methods An anonymous 25-question survey was distributed at an American College of Obstetricians and Gynecologists (ACOG) joint ...
Rachel Towns +3 more
doaj +1 more source