Results 291 to 300 of about 49,757 (329)

Development of chitosan sponges for buccal administration of insulin

Carbohydrate Polymers, 2007
Abstract This paper describes the development of a new highly porous, flexible device for buccal peptide administration by a very simple and mild casting/freeze-drying procedure. It consists of a mucoadhesive chitosan layer containing the peptide drug and an impermeable protective layer made of ethylcellulose.
María J. Alonso, Desirée Teijeiro-Osorio, A. Portero, Carmen Remuñán-López   +3 more
openaire   +2 more sources

Absorption behavior of etilefrine after buccal administration in rats

International Journal of Pharmaceutics, 2018
Etilefrine hydrochloride (ET-HCl) is used in the treatment of hypotension. Dosage forms of orally administered tablets and parenteral injections are clinically available, but exhibit unfavorable characteristics, including cardiac toxicity, headaches, and damage at the injection site for the parenteral dosage form, and initially high plasma levels, fast
Osamu Sakata, Hiraku Onishi
openaire   +3 more sources

Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits

Current Drug Delivery, 2017
Prevalence of oral mucosal fungal infections increases with the frequent administration of antibiotics, corticosteroids and immunosuppressive drugs. Therapeutically used antifungals are usually associated with a variety of drug interactions.
Ivana Lukášová, Jan Muselík, Karel Hauptman, David Vetchý, Vladimir Jekl, Markéta Gajdošová, Zdeněk Knotek, Jan Juřica, Jan Gajdziok   +8 more
openaire   +3 more sources

Bioavailability of morphine after administration of a new bioadhesive buccal tablet

Biopharmaceutics & Drug Disposition, 1998
A new bioadhesive buccal morphine tablet was developed for controlled release delivery of drug and improved bioavailability compared with oral controlled release tablet. In order to characterize the pharmacokinetic properties of this bioadhesive buccal formulation, a bioavailability study was performed in 12 healthy volunteers who received: a 30 mg ...
J.-M. Aiache, P. Sandouk, Marvin C. Meyer, F. Touaref, E. Beyssac, L. Jacob   +5 more
openaire   +3 more sources

Sublingual and buccal drug administration in medical emergencies

Medicina Clínica (English Edition)
Drug administration is crucial to achieve effective therapeutic drug outcomes. In medical emergencies, it is particularly convenient to use drugs that could be administered as an alternative to traditional routes (as oral or intravenous routes), that are not always suitable in these situations. Thus, sublingual and buccal routes offer an alternative to
Joan Ramon, Roma, Pedro, Castro Rebollo, Carla, Bastida   +2 more
openaire   +2 more sources

Comparison of Oxycodone Pharmacokinetics after Buccal and Sublingual Administration in Children

Clinical Pharmacokinetics, 2006
We evaluated and compared the pharmacokinetics of two oral administration routes of oxycodone parenteral liquid (10 mg/mL)--single buccal and sublingual administration--in 30 generally healthy awake children, aged 6-91 months.Two groups of children undergoing inpatient surgery were enrolled.
Merja Lasalmi, Kari Vanamo, Ilpo Rasanen, Veli-Pekka Ranta, Sanna Lehtola, Ilkka Ojanperä, Hannu Kokki   +6 more
openaire   +3 more sources

Comparison of misoprostol plasma concentrations following buccal and sublingual administration

Contraception, 2005
New indications for misoprostol include medical abortion, cervical softening, induction of labor and treatment of postpartum hemorrhage. Various routes of misoprostol administration under study include oral, vaginal, buccal, sublingual and rectal.This was an open-label, randomized, cross-over study of the pharmacokinetic differences of buccal vs ...
Eric A. Schaff, Stephen L. Fielding, Robert DiCenzo   +2 more
openaire   +3 more sources

Drug Delivery Approaches for Buccal and Sublingual Administration

Drug Research
AbstractBoth local and systemic medication delivery benefit greatly from the sublingual and buccal modes of administration. They have shown to be a successful substitute for the conventional oral route, particularly in situations requiring a quick commencement of action. Via venous drainage to
Asad, Ahmad, Juber, Akhtar, Mohammad, Ahmad, Rufaida, Wasim, Mohammad Irfan, Khan   +4 more
openaire   +2 more sources

Mucoadhesive gels for buccal administration of chloexidine digluconate

2005
Chlorhexidine (CHX) is a bis-bis-guanide widely used to treat skin and mucosa infections, efficient against a wide range of microbial species. The aim of this work was to design and evaluate gels containing CHX associated to mucoadhesive and swelling agents, such as CMC, HPMC, HPC and Poloxamer, to control both the residence time in the oral cavity and
G. C. Ceschel, BERGAMANTE, VALENTINA, ORIENTI, ISABELLA, ZUCCARI, GUENDALINA, C. Ronchi, FINI, ADAMO   +5 more
openaire   +4 more sources

In vivo absorption study of ritodrine hydrochloride in the buccal administration to rats

Drug Development and Industrial Pharmacy, 2012
Although ritodrine (RD)-hydrochloride (HCl), named RD-HCl, is widely used in the treatment of premature labor by intravenous prolonged infusion or frequent oral dosing of tablets, those administrations often lower patients' quality of life (QOL) or cause undesirable side effects, such as tachycardia; therefore, in this study, the potential usefulness ...
Osamu Sakata, Hiraku Onishi
openaire   +2 more sources