Results 291 to 300 of about 53,364 (321)

Drug Delivery Approaches for Buccal and Sublingual Administration

Drug Research
AbstractBoth local and systemic medication delivery benefit greatly from the sublingual and buccal modes of administration. They have shown to be a successful substitute for the conventional oral route, particularly in situations requiring a quick commencement of action. Via venous drainage to
Asad, Ahmad, Juber, Akhtar, Mohammad, Ahmad, Rufaida, Wasim, Mohammad Irfan, Khan   +4 more
openaire   +2 more sources

Development of mucoadhesive patches for buccal administration of ibuprofen

Journal of Controlled Release, 2004
A new formulation for topical administration of drugs in the oral cavity has been developed using several film-forming and mucoadhesive polymers. The films have been evaluated in terms of swelling, mucoadhesion and organoleptic characteristics. The best film, containing polyvinylpyrrolidone (PVP) as film-forming polymer and carboxymethylcellulose ...
PERIOLI, Luana, AMBROGI, Valeria, Angelici F., RICCI, Maurizio, GIOVAGNOLI, Stefano, Capuccella M., ROSSI, Carlo   +6 more
openaire   +3 more sources

Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits

Current Drug Delivery, 2017
Prevalence of oral mucosal fungal infections increases with the frequent administration of antibiotics, corticosteroids and immunosuppressive drugs. Therapeutically used antifungals are usually associated with a variety of drug interactions.
Ivana, Lukášová, Jan, Muselík, David, Vetchý, Jan, Gajdziok, Markéta, Gajdošová, Jan, Juřica, Zdeněk, Knotek, Karel, Hauptman, Vladimír, Jekl   +8 more
openaire   +2 more sources

Absorption behavior of etilefrine after buccal administration in rats

International Journal of Pharmaceutics, 2018
Etilefrine hydrochloride (ET-HCl) is used in the treatment of hypotension. Dosage forms of orally administered tablets and parenteral injections are clinically available, but exhibit unfavorable characteristics, including cardiac toxicity, headaches, and damage at the injection site for the parenteral dosage form, and initially high plasma levels, fast
Hiraku, Onishi, Osamu, Sakata
openaire   +2 more sources

Pharmacokinetics of testosterone after percutaneous gel or buccal administration

Fertility and Sterility, 2001
To determine the pharmacokinetics of testosterone following its administration using transdermal gel or buccal lozenges.Pilot study.University-based hospital.Ten bilaterally oophorectomized women.Daily micronized testosterone gel (1 mg) and testosterone propionate lozenge (1 mg).Total testosterone, androstenedione, dihydrotestosterone, 3alpha ...
C C, Slater, I, Souter, C, Zhang, C, Guan, F Z, Stanczyk, D R, Mishell   +5 more
openaire   +2 more sources

Development of Mucoadhesive Patches for Buccal Administration of Carvedilol

Current Drug Delivery, 2007
A buccal patch for systemic administration of carvedilol in the oral cavity has been developed using two different mucoadhesive polymers. The formulations were tested for in vitro drug permeation studies, buccal absorption test, in vitro release studies, moisture absorption studies and in vitro bioadhesion studies.
Y Vamshi, Vishnu, K, Chandrasekhar, G, Ramesh, Y Madhusudan, Rao   +3 more
openaire   +2 more sources

Comparison of misoprostol plasma concentrations following buccal and sublingual administration

Contraception, 2005
New indications for misoprostol include medical abortion, cervical softening, induction of labor and treatment of postpartum hemorrhage. Various routes of misoprostol administration under study include oral, vaginal, buccal, sublingual and rectal.This was an open-label, randomized, cross-over study of the pharmacokinetic differences of buccal vs ...
Eric A, Schaff, Robert, DiCenzo, Stephen L, Fielding   +2 more
openaire   +2 more sources

Mucoadhesive gels for buccal administration of chloexidine digluconate

2005
Chlorhexidine (CHX) is a bis-bis-guanide widely used to treat skin and mucosa infections, efficient against a wide range of microbial species. The aim of this work was to design and evaluate gels containing CHX associated to mucoadhesive and swelling agents, such as CMC, HPMC, HPC and Poloxamer, to control both the residence time in the oral cavity and
G. C. Ceschel, BERGAMANTE, VALENTINA, ORIENTI, ISABELLA, ZUCCARI, GUENDALINA, C. Ronchi, FINI, ADAMO   +5 more
openaire   +4 more sources

Pethidine is Unsuitable for Buccal Administration

Pharmacology & Toxicology, 1990
Christrup, Lona Louring, Bonde, J, Wulff, M B, Armandi, H B, Flachs, H   +4 more
openaire   +3 more sources

ELECTROSPUN NANOFIBER FILMS FOR BUCCAL ADMINISTRATION OF GLIBENCLAMIDE

INDIAN DRUGS
This study aimed to develop and evaluate glibenclamide-loaded electrospun nanofiber films for buccal delivery, a promising strategy to overcome the solubility and bioavailability challenges associated with this biopharmaceutics classification system class II drug.
Sreehari S. Nair, Shradha B. Adhalrao, Dhanashree P. Sanap, Kisan R. Jadhav   +3 more
openaire   +1 more source