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Buccal delivery of insulin: the time is now
Drug Development Research, 2006AbstractThe burgeoning numbers of individuals with diabetes mellitus and prediabetes, in particular Type 2 including large numbers of children, open up not only the classic risks for microvascular disease but the earlier and incapacitating risk for macrovascular disease. Oral hypoglycemic agents and insulin sensitizers have not been adequate to control
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The RapidMist™ System for Buccal Delivery of Insulin [PDF]
Multiple insulin injections are often required in patients with diabetes mellitus in order to achieve optimal glycemic control. This may reduce patient compliance and increase the risk of long-term microvascular complications in patients. To improve patient compliance, research efforts are focused towards development of needle-free method for insulin ...
Sanjay Bansal+2 more
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Buccal delivery systems using hydrogels
Advanced Drug Delivery Reviews, 1993Abstract Buccal or oral mucosal routes have various advantages for the administration of drugs which undergo severe first-pass metabolism. Hydrogel seemed an appropriate material for the buccal delivery systems because of its mucoadhesiveness, sustained-release property, good feel in the mouth, and safety.
Tsuneji Nagai, Yoshiharu Machida
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Novel nano spanlastic carrier system for buccal delivery of lacidipine
Journal of Drug Delivery Science and Technology, 2021Cleona Elizabeth Mary DCruz+3 more
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Recent developments in buccal and sublingual delivery systems
Expert Opinion on Drug Delivery, 2012There have been several advances in the delivery of drugs through the buccal mucosa over the last 5 years, which have resulted in a number of new buccal delivery products appearing on the market.This review discusses the most recent developments in the area of buccal and sublingual drug delivery, with a focus on marketed drugs. Likely future directions
Sevda Şenel+3 more
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Study on a Nanoparticle System for Buccal Delivery of Insulin
2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 2005In this paper, a nanoparticle system of insulin (NSI) was prepared for buccal transmucosal delivery of insulin. The average size of the suspending particles was 67.5 nm, and a possible microstructure of the nanoparticles in the system was proposed. The transmucosal ability of insulin was evaluated in rabbits from the views of the hypoglycaemic rate and
Kaixun Huang+5 more
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In-vitro evaluation of mucoadhesive in-situ nanogel of celecoxib for buccal delivery.
Annales Pharmaceutiques Françaises, 2021H. V. Raghavendra Reddy+1 more
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Materials Science and Engineering C: Materials for Biological Applications, 2021
Beatriz Ribeiro Amaral+8 more
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Beatriz Ribeiro Amaral+8 more
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Mucoadhesive zein/beta-cyclodextrin nanoparticles for the buccal delivery of curcumin.
International journal of pharmaceutics, 2020Diletta Esposito+5 more
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