Results 311 to 320 of about 1,568,027 (370)

A Guide for Implementing DPYD Genotyping for Systemic Fluoropyrimidines into Clinical Practice

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1194-1208, May 2025.
The safety of systemic fluoropyrimidines (e.g., 5‐fluorouracil, capecitabine) is impacted by germline genetic variants in DPYD, which encodes the dihydropyrimidine dehydrogenase (DPD) enzyme that functions as the rate‐limiting step in the catabolism of this drug class.
Teresa T. Ho, D. Max Smith, Christina L. Aquilante, Emily J. Cicali, Nihal El Rouby, Daniel L. Hertz, Iman Imanirad, Jai N. Patel, Stuart A. Scott, Sandra M. Swain, Sony Tuteja, J. Kevin Hicks, on behalf of the Pharmacogenomics Global Research Network Publication Committee   +12 more
wiley   +1 more source

Novel Buccal Xanthan Gum-Hyaluronic Acid Eutectogels with Dual Anti-Inflammatory and Antimicrobial Properties. [PDF]

Gels
Anuța V, Nica MA, Prisada RM, Popa L, Velescu BȘ, Marinas IC, Gaboreanu DM, Ghica MV, Cocoș FI, Nicolae CA, Dinu-Pîrvu CE.   +10 more
europepmc   +1 more source

Natural Epithelial Barrier Integrity Enhancers-Citrus medica and Origanum dayi Extracts. [PDF]

Gels
Coopersmith S, Rahamim V, Drori E, Miloslavsky R, Kozlov R, Gorelick J, Azagury A.   +6 more
europepmc   +1 more source

Monochorionic Diamniotic Twins with Sex Discordance: Case Series. [PDF]

Diagnostics (Basel)
Sala V, Spaccini L, Faiola S, Casati D, Laoreti A, Tollenaar LSA, Lopriore E, Lanna MM.   +7 more
europepmc   +1 more source

Pharmacokinetic Characterization of Labetalol in Pregnancy (The CLIP Study): A Prospective Observational Longitudinal Pharmacokinetic/Pharmacodynamic Cohort Study During Pregnancy and Postpartum. [PDF]

J Clin Med
Bhamidipaty-Pelosi S, Muralidharan S, Yeley BC, Haas DM, Quinney SK.   +4 more
europepmc   +1 more source

Differential Enhancement of Fat-Soluble Vitamin Absorption and Bioefficacy via Micellization in Combination with Selected Plant Extracts In Vitro. [PDF]

Nutrients
Steinbauer S, Wallner M, Karl LM, Gramatte T, Essl K, Iken M, Weghuber J, Blank-Landeshammer B, Röhrl C.   +8 more
europepmc   +1 more source

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Advances in buccal and oral delivery of insulin

International Journal of Pharmaceutics, 2023
Diabetes mellitus is a metabolic endocrine disease characterized by chronic hyperglycemia with disturbances in metabolic processes, such as those related to carbohydrates, fat, and protein. There are two main types of this disease: type 1 diabetes (T1D) and type 2 diabetes (T2D). Insulin therapy is pivotal to the management of diabetes.
Amani, Elsayed, Mayyas, Al-Remawi, Nisrein, Jaber, Khalid M, Abu-Salah   +3 more
openaire   +3 more sources

Adhesive alginate for buccal delivery in aphthous stomatitis

Carbohydrate Research, 2019
Recurrent aphthous stomatitis being the most common chronic disease of the oral cavity affects 5-25% of the population.This study goals to develop a novel polymeric excipient based on alginate with enhanced mucoadhesion and controlled release for buccal therapy of aphthae.Sulfhydryl groups of amino acid cysteine (SH) was anchored on the polymeric ...
Philip Küppers, Flavia Laffleur, Flavia Laffleur   +2 more
openaire   +3 more sources

The Potential of Statins for Buccal Delivery [PDF]

Journal of Molecular Pharmaceutics & Organic Process Research, 2014
Statins minimize the endogenous synthesis of cholesterol preventing the onset and development of artherosclerosis and are therefore used as an effective treatment against primary hypercholesterolemia. Statins do exhibit antiinflammatory, vasculoprotective, and antioxidant effects.
Anusha T, Prathyusha G, Gannu Praveen Kumar, Syeda Jaweria, Geethika R   +4 more
openaire   +1 more source

Inhibitory Effect of a KSL-W Peptide-Loaded Poloxamer 407-Based Microemulsions for Buccal Delivery on Fusobacterium nucleatum Biofilm.

Journal of Biomedical Nanotechnology, 2020
KSL-W peptide has demonstrated antibacterial and antifungal activity and inhibitory effects against oral biofilm. This study aimed to check out the effect of chlorhexidine (CLX) or KSL-W peptide-loaded poloxamer 407-based microemulsions for buccal ...
J. Bernegossi, C. R. Fontana, K. Caiaffa, C. Duque, M. Chorilli   +4 more
semanticscholar   +1 more source