Results 321 to 330 of about 1,568,027 (370)
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Drug Development and Industrial Pharmacy, 2003
The oral cavity is an attractive site for drug delivery due to ease of administration and avoidance of possible drug degradation in gastrointestinal tract and first-pass metabolism. Buccal drug delivery specifically refers to the delivery of drugs within/ through buccal mucosa to affect local/systemic pharmacological actions.
Paul Wan Sia Heng, Jinsong Hao
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The oral cavity is an attractive site for drug delivery due to ease of administration and avoidance of possible drug degradation in gastrointestinal tract and first-pass metabolism. Buccal drug delivery specifically refers to the delivery of drugs within/ through buccal mucosa to affect local/systemic pharmacological actions.
Paul Wan Sia Heng, Jinsong Hao
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A Comprehensive Review on Buccal Drug Delivery System
Asian Journal of Pharmacy and Technology, 2023This analysis focuses primarily on the several benefits of the buccal drug delivery system (BDDS) over the traditional and systemic formulation. Bypassing first pass metabolism, it aids in improving bioavailability.
Namita S. Bhosale +7 more
semanticscholar +1 more source
Advances in Buccal Drug Delivery
Critical Reviews in Therapeutic Drug Carrier Systems, 2005The buccal route offers an attractive alternative for systemic drug delivery of drugs because of better patient compliance, ease of dosage form removal in emergencies, robustness, and good accessibility. Use of buccal mucosa for drug absorption was first attempted by Sobrero in 1847, and since then much research was done to deliver drugs through this ...
Xiaoling Li +3 more
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AAPS PharmSciTech, 2020
Ciclopirox olamine (CPO) is a topical wide-spectrum antimycotic agent that possesses antifungal, antibacterial and anti-inflammatory activities. Loading CPO into a hybridized vesicular system is expected to enhance its buccal permeation and hence ...
M. AbouSamra +3 more
semanticscholar +1 more source
Ciclopirox olamine (CPO) is a topical wide-spectrum antimycotic agent that possesses antifungal, antibacterial and anti-inflammatory activities. Loading CPO into a hybridized vesicular system is expected to enhance its buccal permeation and hence ...
M. AbouSamra +3 more
semanticscholar +1 more source
Controlled buccal delivery of buprenorphine
Journal of Controlled Release, 1993Abstract Buprenorphine is a potent opiate agonist-antagonist used in the treatment of both acute and chronic pain. Like many opiates, it has low oral bioavailability due to both presystemic metabolism in the wall of the gastrointestinal tract and extensive first pass metabolism.
J.P. Cassidy, E. Quadros, N.M. Landzert
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Buccal delivery for peptide drugs
Journal of Controlled Release, 1992Abstract The non-parenteral delivery of peptides via mucosal routes is essential for the enlargement of the therapeutic benefit of various oligopeptides. Among the routes under discussion the buccal mucosa was found to allow permeation of therapeutically relevant doses, e.g.
Hans P. Merkle, Gregor Wolany
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Expert Opinion on Drug Delivery, 2005
Buccal formulations have been developed to allow prolonged localised therapy and enhanced systemic delivery. The buccal mucosa, however, while avoiding first-pass effects, is a formidable barrier to drug absorption, especially for biopharmaceutical products (proteins and oligonucleotides) arising from the recent advances in genomics and proteomics. The
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Buccal formulations have been developed to allow prolonged localised therapy and enhanced systemic delivery. The buccal mucosa, however, while avoiding first-pass effects, is a formidable barrier to drug absorption, especially for biopharmaceutical products (proteins and oligonucleotides) arising from the recent advances in genomics and proteomics. The
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Drug Development and Industrial Pharmacy, 1995
AbstractBuccal administration offers certain unique advantages for the drugs which cannot be easily or efficiently administered by oral or intravenous route. However, transbucccal delivery receiived relatively little attention and few well-controlled studies of buccal mucosa permeability have been conducted.
N. Chidambaram, A. K. Srivatsava
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AbstractBuccal administration offers certain unique advantages for the drugs which cannot be easily or efficiently administered by oral or intravenous route. However, transbucccal delivery receiived relatively little attention and few well-controlled studies of buccal mucosa permeability have been conducted.
N. Chidambaram, A. K. Srivatsava
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2011
The buccal cavity can be most useful for delivery of drugs for systemic effects. Advantages can include rapid onset of action, avoidance of presystemic elimination, which may include gastrointestinal degradation, first-pass clearance by the liver, or transformation by intestinal mucosal enzymes, e.g., CYP450.
Rick S. Chan +2 more
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The buccal cavity can be most useful for delivery of drugs for systemic effects. Advantages can include rapid onset of action, avoidance of presystemic elimination, which may include gastrointestinal degradation, first-pass clearance by the liver, or transformation by intestinal mucosal enzymes, e.g., CYP450.
Rick S. Chan +2 more
openaire +2 more sources
Buccal Delivery Systems for Peptides
American Journal of Drug Delivery, 2005This review aims to illustrate the potential of the buccal route for delivery of peptide drugs. Compared with the oral, nasal, and rectal routes for drug delivery, the buccal route presents advantages such as an efficient blood supply and relatively low enzymatic activity.
ROSSI, SILVIA STEFANIA +2 more
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