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Drug Delivery of Peptides: The Buccal Route [PDF]

, 1986
Peptides and proteins are currently emerging as a major class of future drugs. So far the research in this field is mainly focused on basic research covering isolation, synthesis, analysis, and biological and clinical effects. However, increasing attention is now also given to considerations regarding suitable dosage forms and routes of absorption.
Hans Peter Prof. Dr. Merkle, Reinhold Anders, Werner Schurr, Jürgen Kurt Dr. Sandow   +3 more
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Mucoadhesive polymers for buccal drug delivery

Drug Development and Industrial Pharmacy, 2014
Raising the concept of mucoadhesion in the 1980s, the use of mucoadhesive polymers for buccal drug delivery has been the subject of interest. Buccal route is one of the non-invasive routes comprising several advantages such as targeting the specific tissue (I), bypassing the first-pass effect (II) as well as higher patient compliance (III) and higher ...
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Buccal/gingival drug delivery systems

Journal of Controlled Release, 1987
Abstract As a continuation of our previous work on oral mucosal adhesive tablets for the administration of insulin and for treatment of aphtous stomatitis, we have investigated a similar type of dosage form using hydroxypropyl cellulose, Carbopol and lidocaine of a model drug for the treatment of toothache by applying the system to the human gingiva.
Tsuneji Nagai, Ryoji Konishi
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Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles - An update.

International journal of pharmaceutics, 2023
Varsha V Nair, Pablo Cabrera, Constanza Ramírez-Lecaros, Miguel O. Jara, David J Brayden, J. Morales   +5 more
semanticscholar   +1 more source

Ketobemidone prodrugs for buccal delivery.

Acta pharmaceutica Nordica, 1991
Various carboxylic acid and carbonate esters of the opioid analgesic ketobemidone were prepared and assessed as potential prodrugs with the aim of obtaining a ketobemidone formulation suitable for buccal or sublingual absorption. The chemical stability, enzymatic hydrolysis and lipophilicity characteristics of the esters were studied using HPLC assay ...
Bach Hansen, L., Christrup, Lona Louring, Bundgaard, H.   +2 more
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Drug delivery via the buccal mucosa

Pharmaceutical Science & Technology Today, 1998
Abstract A candidate drug has entered the development phase but there are problems in drug delivery. The oral bioavailability is low or provides the wrong plasma profile. It is usual that other routes of administration are proposed such as nasal, pulmonary, transdermal, buccal or rectal drug delivery.
Janet A.J Hoogstraate, Philip W Wertz, Philip W Wertz   +2 more
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Chemical Enhancers in Buccal and Sublingual Delivery

International Journal of Pharmaceutical Sciences and Nanotechnology, 2011
Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs with superior pharmacological efficacy, site specificity and devoid of toxic effects. However, the major problem for the oral delivery of these therapeutic agents is their extensive presystemic metabolism, instability in acidic ...
Naveen C, T. Rama Rao, Venkateshwar Rao P, Kiran kumar Y   +3 more
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Double-phase hydrogel for buccal delivery of tramadol

Drug Development and Industrial Pharmacy, 2011
Treatment of chronic pain is complicated by the evidence that abuse of prescription opioids is rising; therefore, in many cases, chronic pain remains undertreated. Tramadol is an atypical central analgesic with a mixed mechanism of action offering many advantages over conventional opioids.We exploited the nonopioid action of tramadol, by bypassing the ...
Azza A. Mahmoud, Gina S. El-Feky, Rabab Kamel   +2 more
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Feasibility of mucoadhesive chitosan maleimide-coated liposomes for improved buccal delivery of a protein drug

Journal of Drug Delivery Science and Technology, 2022
Nitjawan Sahatsapan, Boonnada Pamornpathomkul, T. Rojanarata, T. Ngawhirunpat, Raksawan Poonkhum, P. Opanasopit, Prasopchai Tonglairoum Patrojanasophon   +6 more
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Buccal delivery systems using hydrogels

Advanced Drug Delivery Reviews, 1993
Abstract Buccal or oral mucosal routes have various advantages for the administration of drugs which undergo severe first-pass metabolism. Hydrogel seemed an appropriate material for the buccal delivery systems because of its mucoadhesiveness, sustained-release property, good feel in the mouth, and safety.
Tsuneji Nagai, Yoshiharu Machida
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